Abstract:
:We report here the synthesis of novel 5'-linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5'-terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotide serves to deliver a nuclease-resistant reactive drug-like molecule to a cellular target nucleic acid (mRNA or DNA).
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mori K,Subasinghe C,Cohen JSdoi
10.1016/0014-5793(89)80626-xsubject
Has Abstractpub_date
1989-06-05 00:00:00pages
213-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(89)80626-Xjournal_volume
249pub_type
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