Abstract:
:Reg, first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet beta-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. In this study, we analyzed YAC clones containing the four genes and performed two-color FISH to determine the map order of the genes. The human REG family genes are tandemly ordered in the 95-kbp DNA region of chromosome 2p12 as follows: 2cen-HIP/PAP-RS-REG I alpha-REG I beta-ptel.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Miyashita H,Nakagawara K,Mori M,Narushima Y,Noguchi N,Moriizumi S,Takasawa S,Yonekura H,Takeuchi T,Okamoto Hdoi
10.1016/0014-5793(95)01381-4subject
Has Abstractpub_date
1995-12-27 00:00:00pages
429-33issue
3eissn
0014-5793issn
1873-3468pii
0014579395013814journal_volume
377pub_type
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