Abstract:
:D-Aspartate increases human chorionic gonadotropin-induced testosterone production in purified rat Leydig cells. L-Aspartate, D-,L-glutamate or D-,L-asparagine could not substitute for D-aspartate and this effect was independent of glutamate receptor activation. Testosterone production was enhanced only in cells cultured with D-aspartate for more than 3 h. The increased production of testosterone was well correlated with the amounts of D-aspartate incorporated into the Leydig cells, and L-cysteine sulfinic acid, an inhibitor of D-aspartate uptake, suppressed both testosterone production and intracellular D-aspartate levels. D-Aspartate therefore is presumably taken up into cells to increase steroidogenesis. Intracellular D-aspartate probably acts on cholesterol translocation into the inner mitochondrial membrane, the rate-limiting process in steroidogenesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nagata Y,Homma H,Lee JA,Imai Kdoi
10.1016/s0014-5793(99)00045-9keywords:
subject
Has Abstractpub_date
1999-02-12 00:00:00pages
160-4issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00045-9journal_volume
444pub_type
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