Abstract:
:PCR-coupled cDNA subtraction hybridization was adapted to identify the genes expressed in the adrenocortical tissues from high salt diet-treated rat. A novel cDNA clone, termed salt-inducible kinase (SIK), encoding a polypeptide (776 amino acids) with significant similarity to protein serine/ threonine kinases in the SNF1/AMPK family was isolated. An in vitro kinase assay demonstrated that SIK protein had autophosphorylation activity. Northern blot revealed that SIK mRNA levels were markedly augmented by ACTH treatment both in rat adrenal glands and in Y1 cells. SIK may play an important role in the regulation of adrenocortical functions in response to high plasma salt and ACTH stimulation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wang Z,Takemori H,Halder SK,Nonaka Y,Okamoto Mdoi
10.1016/s0014-5793(99)00708-5keywords:
subject
Has Abstractpub_date
1999-06-18 00:00:00pages
135-9issue
1-2eissn
0014-5793issn
1873-3468pii
S0014579399007085journal_volume
453pub_type
杂志文章相关文献
FEBS LETTERS文献大全abstract::To determine the regulatory mechanism for human tyrosine hydroxylase, we examined modulations of the activity of the enzyme from human pheochromocytoma by cyclic AMP-dependent protein kinase, calmodulin-dependent protein kinase II and polyanion. The most remarkable activation was observed when the enzyme was assayed a...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(89)80927-5
更新日期:1989-08-14 00:00:00
abstract::The Escherichia coli twin-arginine translocation (Tat) system serves to export fully folded protein substrates across the bacterial cytoplasmic membrane. Respiratory [NiFe] hydrogenases are synthesised as precursors with twin-arginine signal peptides and transported as large, cofactor-containing, multi-subunit complex...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(03)00802-0
更新日期:2003-08-14 00:00:00
abstract::The aim of the present study was to investigate homoharringtonine alkaloid effect on: (i) the nonenzymatic and eEF-1-dependent Phe-tRNAPhe binding to poly(U)-programmed human placenta 80 S ribosomes; (ii) diphenylalanine synthesis accompanying nonenzymatic Phe-tRNAPhe binding; and (iii) acetylphenylalanyl-puromycin fo...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(89)81546-7
更新日期:1989-11-06 00:00:00
abstract::Peptide T, an octapeptide of sequence ASTTTNYT that binds to human T cells, was studied as a zwitterion in DMSOd6 solution by means of proton NMR spectroscopy at 500 MHz. The unusual dispersion of the resonances of residues of the same type (T) makes it possible to assign all resonances to specific residues by means o...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(88)80723-3
更新日期:1988-04-11 00:00:00
abstract::Anandamide loses its cannabimimetic activities upon hydrolysis to arachidonic acid and ethanolamine. So far the anandamide hydrolyzing activity widely distributed in mammalian organs has been attributed exclusively to an enzyme referred to as anandamide amidohydrolase with an optimum pH around 9. We found another enzy...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)00820-0
更新日期:1999-07-09 00:00:00
abstract::By co-expression of heme oxygenase and various bilin reductase(s) in a single operon in conjunction with apophytochrome using two compatible plasmids, we developed a system to produce phytochromes with various chromophores in Escherichia coli. Through the selection of different bilin reductases, apophytochromes were a...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2006.01.051
更新日期:2006-02-20 00:00:00
abstract::Using model spontaneously reverting cell lines, c-jun, junB, junD and c-fos oncogene expression was investigated. c-jun, but not junB, junD or c-fos, was overexpressed in highly tumorigenic clones. The reversion of cells to the non-tumorigenic phenotype resulted in a dramatic decrease in c-jun expression. CAT assays r...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)01266-0
更新日期:1994-12-19 00:00:00
abstract::Hepatocyte tight junctional permeability has been shown to be regulated by hormones that exert their effects via phospholipase C activation. However, the precise transduction pathway involved in this effect is not known. The present study has employed the selective inhibitor of microsomal Ca2+ sequestration, 2,5-di(te...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(91)80209-l
更新日期:1991-03-11 00:00:00
abstract::The retinal pigment epithelium-specific 65 kDa (RPE65) isomerase plays a pivotal role in photoreceptor survival and function. RPE65-catalyzed synthesis of 11-cis-retinol from all-trans-retinyl esters in the visual cycle is negatively regulated, through a heretofore unknown mechanism, by the fatty acid transport protei...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13633
更新日期:2020-02-01 00:00:00
abstract::Cyclic ADP-ribose (cADPR) is a natural metabolite of beta-NAD+ with a potent Ca2+-mobilizing activity in different cell types, including T-lymphocytes. We investigated (i) whether stimulation of T-lymphocytes with different agonists affects the intracellular concentration of cADPR, and (ii) whether the lymphocyte anti...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)01396-9
更新日期:1998-11-20 00:00:00
abstract::Amyloid-beta peptide (Abeta), the major constituent of senile plaques in the Alzheimer's disease (AD) brain, is the main source of oxidative stress leading to neurodegeneration. The methionine residue in this peptide is reported to be responsible for neurotoxicity. Structurally similar substitution with methionine 35 ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2007.02.038
更新日期:2007-04-03 00:00:00
abstract::Nitric oxide, as well as being a major regulator of vascular reactivity, has been shown to be one of the mediators of cytotoxicity in macrophages. This cytotoxic effect seems to be due to the interaction between nitric oxide and oxygen-related free radicals. This study shows that, in vitro, nitric oxide reacts with hy...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(93)80621-z
更新日期:1993-04-19 00:00:00
abstract::Three DNA restriction fragments designated tyrT, 102-mer and 70-mer, have been used as substrates for footprinting studies using DNase I in the presence of the structurally similar antibiotics chartreusin and elsamicin A. The sequence-selective binding sites of the antibiotics can be mapped in regions which are rich i...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(91)80872-z
更新日期:1991-11-04 00:00:00
abstract::Sphingolipids are implied in several regulatory processes, including cell death. Levels of the free sphingobase t18:0 (phytosphingosine) increase in Arabidopsis in response to the bacterial pathogen Pseudomonas syringae. To gain information on sphingobase-induced signaling, we determined kinetics of leaf reactive oxyg...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2011.08.016
更新日期:2011-10-03 00:00:00
abstract::G-quadruplex ligands DODC and TMPyP4 have different binding modes to quadruplex structure and cause cell proliferation arrest. Here we showed that DODC was more efficient in cell growth inhibition than TMPyP4. Both G-quadruplex ligands induced nuclear-cytoplasmic shuttling and accumulation of TERT in mitochondria. Thi...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2013.04.010
更新日期:2013-06-05 00:00:00
abstract::Several catalytic properties of the hydrogenase from Scenedesmus obliquus have been examined to optimize the purification conditions. The Km-value for H2-evolution in the presence of the most effective electron mediator methylviologen is 0.66 mM. The pH-optimum is 6.3, the temperature-optimum is 50 degrees C and the e...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(93)81030-4
更新日期:1993-07-19 00:00:00
abstract::Exposure of human proliferative cells to subcytotoxic stress triggers stress-induced premature senescence (SIPS) which is characterized by many biomarkers of replicative senescence. Proteomic comparison of replicative senescence and stress-induced premature senescence indicates that, at the level of protein expression...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)03604-9
更新日期:2002-11-20 00:00:00
abstract::The H3K9 protein lysine methyltransferase SUV39H2 was reported to methylate K134 of H2AX and stimulate H2AX phosphorylation during DNA damage response [Sone K et al. (2014) Nat Commun 5, 5691]. However, the sequence context of H2AX-K134 differs from the specificity of SUV39H2. We performed in vitro methylation reactio...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12216
更新日期:2016-06-01 00:00:00
abstract::Sulfate assimilation pathway is highly responsive to changes in environment, but the mechanisms of such regulation are only slowly beginning to unravel. Here we show evidence that PHYTOCHROME AND FLOWERING TIME 1 (PFT1) may be another component of the sulfate assimilation regulatory circuit. Transcriptional regulation...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2014.02.031
更新日期:2014-04-02 00:00:00
abstract::F-box proteins play pivotal roles in multiple cellular processes; however, little is known about their functions in glioma progression. In this study, we found that expression of the F-box and leucine-rich repeat protein 18 (FBXL18) is significantly upregulated in glioma tissues. Depletion of FBXL18 in glioma cells su...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12521
更新日期:2017-01-01 00:00:00
abstract::F0F1 ATP synthases are the smallest rotary motors in nature and work as ATP factories in bacteria, plants and animals. Here we report on the first observation of intersubunit rotation in fully coupled single F0F1 molecules during ATP synthesis or hydrolysis. We investigate the Na+-translocating ATP synthase of Propion...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)03097-1
更新日期:2002-08-14 00:00:00
abstract::The function of the amino- and carboxyl-terminal domains of the yeast plasma membrane H+-ATPase have been investigated by constructing deletions in vitro and selectively expressing the mutant enzymes in vivo. The first 27 amino acids are dispensable but deletion of a further 33 amino acids greatly decreases the appear...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(89)81375-4
更新日期:1989-04-24 00:00:00
abstract::The cytochrome P-450 content of rat hepatocytes declined rapidly over 72 h in culture, due primarily to denaturation to cytochrome P-420. Six different media were investigated for their ability to conserve cytochrome P-450 during culture, and the most successful was a modified Earle's medium. After 72 h culture in thi...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(85)80436-1
更新日期:1985-10-07 00:00:00
abstract::Under destabilising conditions both heat and cold denaturation of yeast phosphoglycerate kinase (PGK) can be observed. According to previous interpretation of experimental data and theoretical calculations, the C-terminal domain should be more stable than the N-terminal domain at all temperatures. We report on thermal...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)01437-6
更新日期:1995-01-30 00:00:00
abstract::Various structural models for amyloid β fibrils have been derived from a variety of experimental techniques. However, these models cannot differentiate between the relative position of the two arms of the β hairpin called the stagger. Amyloid fibrils of various hierarchical levels form left-handed helices composed of ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2013.06.050
更新日期:2013-08-19 00:00:00
abstract::Cerebellar granule cells differentiated in culture were incubated with ganglioside [3H-Sph]GM1 in order to have it inserted into the plasma membrane and metabolized. Among the formed metabolites radioactive sphingosine and ceramide were identified. [3H]Ceramide started to be measurable after 10 min of incubation (puls...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)80193-k
更新日期:1992-03-30 00:00:00
abstract::Tobacco SABP2, a 29kDa protein catalyzes the conversion of methyl salicylic acid (MeSA) into salicylic acid (SA) to induce SAR. Pretreatment of plants with acibenzolar-S-methyl (ASM), a functional analog of salicylic acid induces systemic acquired resistance (SAR). Data presented in this paper suggest that SABP2 catal...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2010.06.046
更新日期:2010-08-04 00:00:00
abstract::The Mahogany/Attractin gene (Atrn) has been proposed as a downstream mediator of Agouti signaling because yellow hair color and obesity in lethal yellow (A(y)) mice are suppressed by the mahogany (Atrn(mg)) mutation. The present study examined the distribution of Atrn mRNA in the brain and spinal cord by in situ hybri...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)01494-5
更新日期:1999-11-26 00:00:00
abstract::We report that sodium butyrate, a natural product of fiber degradation by colonic bacteria, markedly suppresses c-Myc-mediated apoptosis induced in murine plasmacytomas and human Burkitt lymphomas by growth factor deprivation, but not in cell lines devoid of c-myc translocations. Attenuation of cell death is associate...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)00926-0
更新日期:1998-08-28 00:00:00
abstract::We prepared an alpha-bungarotoxin-specific monoclonal antibody that neutralizes the biological activity of the toxin in vivo. The antigenic determinant combining specifically with this antibody was determined on the basis of cross-reaction experiments using three other long neurotoxins and peptide fragments of alpha-b...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(89)81018-x
更新日期:1989-08-28 00:00:00