Abstract:
:During mRNA decoding at the ribosome, deviations from stringent codon identity, or "mistranslation," are generally deleterious and infrequent. Observations of organisms that decode some codons ambiguously, and the discovery of a compensatory increase in mistranslation frequency to combat environmental stress have changed the way we view "errors" in decoding. Modern tools for the study of the frequency and phenotypic effects of mistranslation can provide quantitative and sensitive measurements of decoding errors that were previously inaccessible. Mistranslation with non-protein amino acids, in particular, is an enticing prospect for new drug therapies and the study of molecular evolution.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Moghal A,Mohler K,Ibba Mdoi
10.1016/j.febslet.2014.08.035subject
Has Abstractpub_date
2014-11-28 00:00:00pages
4305-10issue
23eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00662-0journal_volume
588pub_type
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