Regulation of osteopontin expression in rat mesangial cells.

Abstract:

:Hypercellularity and accumulation of extracellular matrix are common responses of renal glomeruli to inflammatory stimuli. Using the differential display approach, we compared the gene expression patterns of proliferating and differentiating rat mesangial cells in two- and three-dimensional cultures. Osteopontin, an extracellular matrix protein, was found to be transcribed, synthesized, and secreted by rat mesangial cells. Osteopontin transcription was not associated with cell proliferation and was found to be FCS-inducible in proliferating cells. Osteopontin expression was independent of exogenously supplied FCS in differentiating cells. The presented data indicate that osteopontin is differentially regulated in proliferating and differentiating mesangial cells.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Pröls F,Heidgress D,Rupprecht HD,Marx M

doi

10.1016/s0014-5793(97)01587-1

subject

Has Abstract

pub_date

1998-01-23 00:00:00

pages

15-8

issue

1

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(97)01587-1

journal_volume

422

pub_type

杂志文章
  • The binding of the B-chain of ricin to Burkitt lymphoma cells. A new approach to ligand-receptor interaction studies.

    abstract::It is shown that conformational changes of receptor proteins brought about by binding of a ligand induce changes in the lipid environment of the receptor that can be monitored by fluorescent lipid probes. On this basis a new approach to studies of ligand-receptor binding is proposed. Using the interaction of the ricin...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(86)80108-9

    authors: Manevich EM,Tonevitsky AG,Bergelson LD

    更新日期:1986-01-06 00:00:00

  • A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates.

    abstract::A novel member of the human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase gene family, designated GalNAc-T7, was cloned and expressed. GalNAc-T7 exhibited different properties compared to other characterized members of this gene family, in showing apparent exclusive specificity for partial...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(99)01268-5

    authors: Bennett EP,Hassan H,Hollingsworth MA,Clausen H

    更新日期:1999-10-29 00:00:00

  • Dexamethasone regulates expression of BRUCE/Apollon and the proliferation of neural progenitor cells.

    abstract::Glucocorticoid hormones (GHs) regulate cell proliferation of neural progenitor cells (NPCs) contributing to reduction of neurogenesis after stress. We show here that dexamethasone (Dex) decreases BRUCE/Apollon (BRUCE) in cultured NPCs in a GH-receptor-dependent manner. Downregulation of BRUCE by Dex or using silencing...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2009.06.018

    authors: Sippel M,Rajala R,Korhonen L,Bornhauser B,Sokka AL,Naito M,Lindholm D

    更新日期:2009-07-07 00:00:00

  • Efficient CD4 binding and immunosuppressive properties of the 13B8.2 monoclonal antibody are displayed by its CDR-H1-derived peptide CB1.

    abstract::A systematic exploration of the V(H)2/V(kappa)12-13 variable domains of the anti-CD4 monoclonal antibody (mAb) 13B8.2 was performed by the Spot method to screen for paratope-derived peptides (PDPs) demonstrating CD4 binding ability. Nine peptides, named CB1 to CB9, were identified, synthesized in a cyclic and soluble ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(01)03036-8

    authors: Bès C,Briant-Longuet L,Cerruti M,De Berardinis P,Devauchelle G,Devaux C,Granier C,Chardès T

    更新日期:2001-11-09 00:00:00

  • Proteinases of betaretroviruses bind single-stranded nucleic acids through a novel interaction module, the G-patch.

    abstract::Retroviral proteinases (PRs) are essential for retrovirus infectivity but the mechanism of their activity regulation is poorly understood. We investigated possible involvement in this process of the C-terminal domain (CTD) of betaretroviral PRs. We found that the presence of CTD attenuates proteolytic activity of Maso...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2004.09.010

    authors: Svec M,Bauerová H,Pichová I,Konvalinka J,Strísovský K

    更新日期:2004-10-08 00:00:00

  • Mutational analysis of 6-aminohexanoate-dimer hydrolase: relationship between nylon oligomer hydrolytic and esterolytic activities.

    abstract::Carboxylesterase (EII') from Arthrobacter sp. KI72 has 88% homology to 6-aminohexanoate-dimer hydrolase (EII) and possesses ca. 0.5% of the level of 6-aminohexanoate-linear dimer (Ald)-hydrolytic activity of EII. To study relationship between Ald-hydrolytic and esterolytic activities, random mutations were introduced ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2006.08.031

    authors: Ohki T,Wakitani Y,Takeo M,Yasuhira K,Shibata N,Higuchi Y,Negoro S

    更新日期:2006-09-18 00:00:00

  • A chloroplastic RNA-binding protein is a new member of the PPR family.

    abstract::P67, a new protein binding to a specific RNA probe, was purified from radish seedlings [Echeverria, M. and Lahmy, S. (1995) Nucleic Acids Res. 23, 4963-4970]. Amino acid sequence information obtained from P67 microsequencing allowed the isolation of genes encoding P67 in radish and Airabidopsis thaliana. Immunolocalis...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(00)01935-9

    authors: Lahmy S,Barnèche F,Derancourt J,Filipowicz W,Delseny M,Echeverria M

    更新日期:2000-09-01 00:00:00

  • Crystallization and preliminary X-ray analysis of methylamine-treated alpha 2-macroglobulin and 3 alpha 2-macroglobulin-proteinase complexes.

    abstract::Crystals of methylamine-treated alpha 2-macroglobulin (alpha 2M-MA), alpha 2-macroglobulin in complex with two molecules of trypsin, alpha 2M-T2, one molecule of plasmin, alpha 2M-PL, and one molecule of plasmin followed by methylamine-treatment, alpha 2M-PL(MA), have reproducibly been obtained using ammonium sulfate ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(91)80881-3

    authors: Andersen GR,Jacobsen L,Thirup S,Nyborg J,Sottrup-Jensen L

    更新日期:1991-11-04 00:00:00

  • Protein NMR resonance assignment by isotropic mixing experiments on random fractionally deuterated samples.

    abstract::The 108-residue protein E. coli thioredoxin has been uniformly enriched to 50% with deuterium at all carbon-bound hydrogen positions. Isotropic mixing (i.e. TOCSY) experiments have been conducted for both the deuterated and natural-abundance samples. Using a 54 ms mixing time correlation peaks can be seen for all four...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(88)80452-6

    authors: LeMaster DM

    更新日期:1988-06-20 00:00:00

  • A sweet code for glycoprotein folding.

    abstract::Glycoprotein synthesis is initiated in the endoplasmic reticulum (ER) lumen upon transfer of a glycan (Glc3Man9GlcNAc2) from a lipid derivative to Asn residues (N-glycosylation). N-Glycan-dependent quality control of glycoprotein folding in the ER prevents exit to Golgi of folding intermediates, irreparably misfolded ...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.febslet.2015.07.021

    authors: Caramelo JJ,Parodi AJ

    更新日期:2015-11-14 00:00:00

  • A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family.

    abstract::We identified a gene encoding a novel secreted protein in mice, humans, and zebrafish. As the protein of 222 amino acids is similar to Brorin, a secreted BMP antagonist, which is a member of the Chordin family, we named it Brorin-like. Recombinant Brorin-like protein weakly but significantly inhibited the activity of ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2009.10.044

    authors: Miwa H,Miyake A,Kouta Y,Shimada A,Yamashita Y,Nakayama Y,Yamauchi H,Konishi M,Itoh N

    更新日期:2009-11-19 00:00:00

  • Identification of a hTid-1 mutation which sensitizes gliomas to apoptosis.

    abstract::Human Tid-1 (hTid-1) is a DnaJ chaperone protein with homology to the Drosophila tumor suppressor Tid56. We report the first case of a tumor-associated mutation at the human TID1 locus, which was identified in the SF767 glioma cell line giving rise to aberrantly high levels of a hTid-1(L) mutant variant. In this study...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2004.11.034

    authors: Trentin GA,He Y,Wu DC,Tang D,Rozakis-Adcock M

    更新日期:2004-12-17 00:00:00

  • Site specificity of p72syk protein tyrosine kinase: efficient phosphorylation of motifs recognized by Src homology 2 domains of the Src family.

    abstract::Protein tyrosine kinase p72syk purified from rat spleen has been assayed for its ability to phosphorylate a number of peptide substrates derived from naturally occurring phospho-acceptor sites. The phosphorylation efficiency is extremely variable, depending on the peptide sequence, with Km values in the 3-1500 microM ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(95)00555-n

    authors: Brunati AM,Donella-Deana A,Ruzzene M,Marin O,Pinna LA

    更新日期:1995-06-26 00:00:00

  • cDNA encoding the chicken ortholog of the mouse dilute gene product. Sequence comparison reveals a myosin I subfamily with conserved C-terminal domains.

    abstract::We report the cDNA-deduced primary structure of the chicken counterpart of the murine dilute gene product, a member of the myosin I family. Comparison of the chicken and mouse sequences reveals a distinct pattern of domains of high and low sequence conservation. An internal deletion of 25 amino acids probably reflects...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(92)81123-4

    authors: Sanders G,Lichte B,Meyer HE,Kilimann MW

    更新日期:1992-10-26 00:00:00

  • Purification and characterization of the head-activator receptor from a multi-headed mutant of Chlorohydra viridissima.

    abstract::In hydra the neuropeptide head activator (HA) is responsible for head-specific growth and differentiation processes. The effects of HA are mediated by high and low affinity receptors on hydra cells. In the current study HA receptors from a multi-headed mutant of Chlorohydra viridissima were solubilized from the membra...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(93)81203-c

    authors: Christians S,Neubauer KH,Ulrich H

    更新日期:1993-01-25 00:00:00

  • Apicomplexan parasites contain a single lipoic acid synthase located in the plastid.

    abstract::Apicomplexan parasites contain a vestigial plastid called apicoplast which has been suggested to be a site of [Fe-S] cluster biogenesis. Here we report the cloning of lipoic acid synthase (LipA) from Toxoplasma gondii, a well known [Fe-S] protein. It is able to complement a LipA-deficient Escherichia coli strain, clea...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(03)00673-2

    authors: Thomsen-Zieger N,Schachtner J,Seeber F

    更新日期:2003-07-17 00:00:00

  • Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.

    abstract::Lysophosphatidic acid (LPA) exerts multiple biological functions through G protein-coupled receptors (EDG2/LPA(1), EDG4/LPA(2), and EDG7/LPA(3)) and is present in serum where it is associated with albumin. In this study we examined LPA activity in various biological fluids by measuring the LPA-induced increase in the ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(02)02976-9

    authors: Hama K,Bandoh K,Kakehi Y,Aoki J,Arai H

    更新日期:2002-07-17 00:00:00

  • Precise mapping of the tms1 binding site on p53.

    abstract::Originally identified as multicopy suppressor of a lethal growth arrest caused by expression of a tumour mutant cDNA of p53 in fission yeast the tms1 gene product was found to form stable complexes with p53 in yeast. By using purified recombinant proteins multimeric complexes of tms1 and p53 could be demonstrated and ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(95)01329-6

    authors: Wagner P,Fuchs A,Prowald A,Montenarh M,Nastainczyk W

    更新日期:1995-12-18 00:00:00

  • The N intermediate of bacteriorhodopsin at low temperatures: stabilization and photoconversion.

    abstract::In aqueous suspensions of purple membranes (pH 10.2, 0.4 M KCl) an intermediate having an absorption maximum at 570-575 nm (at -196 degrees C) was produced by first heating the M intermediate up to -30 degrees C and then stabilizing it by subsequent cooling to -60 degrees C. We suggest that this species is the interme...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(90)80380-2

    authors: Balashov SP,Imasheva ES,Litvin FF,Lozier RH

    更新日期:1990-10-01 00:00:00

  • Effects of Ca2+ and a phorbol ester on insulin secretion from islets of Langerhans permeabilised by high-voltage discharge.

    abstract::Isolated rat islets of Langerhans permeabilised by high-voltage discharge secreted insulin in response to elevations in Ca2+ over the range 100 nM to 10 microM Ca2+. The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), had no effects on insulin secretion in the absence of Ca2+. In the presence of Ca2+ concen...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(85)81002-4

    authors: Jones PM,Stutchfield J,Howell SL

    更新日期:1985-10-21 00:00:00

  • Fraktionierung handelsüblichen insulins. Das verhalten von proinsulin in der ultrazentrifuge.

    abstract::Bovine insulin can be split into several fractions by gel filtration on Sephadex G50. These are, in order of decreasing molecular weight, a new unidentified substance, proinsulin, and a large fraction containing several substances. Ultracentrifugal examination of the proinsulin in acetic acid solution (pH 2.3) gave a ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(68)80122-x

    authors: Zühlke H,Behlke J

    更新日期:1968-12-01 00:00:00

  • Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells.

    abstract::Regulatory protein kinases are involved in various cellular processes such as proliferation, differentiation, and apoptosis. Using cDNA differential display, we identified MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, C...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2004.07.070

    authors: Uesaka T,Kageyama N

    更新日期:2004-08-27 00:00:00

  • Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediate.

    abstract::To date the only tRNAs containing nucleosides modified with a selenium (5-carboxymethylaminomethyl-2-selenouridine and 5-methylaminomethyl-2-selenouridine) have been found in bacteria. By using tRNA anticodon-stem-loop fragments containing S2U, Se2U, or geS2U, we found that in vitro tRNA 2-selenouridine synthase (SelU...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1002/1873-3468.13124

    authors: Sierant M,Leszczynska G,Sadowska K,Komar P,Radzikowska-Cieciura E,Sochacka E,Nawrot B

    更新日期:2018-07-01 00:00:00

  • The role of apoE in inhibitory effects of apoE-rich HDL on platelet function.

    abstract::Apolipoprotein E- (ApoE-) rich high-density lipoprotein (HDL), which was prepared from the bound fraction of normolipemic volunteers on heparin-Sepharose and from a hyperalphalipoproteinemic patient, potently inhibited aggregation of human platelets in a dose-dependent fashion. Dimyristoyl phosphatidylcholine liposome...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(91)80449-d

    authors: Higashihara M,Kinoshita M,Teramoto T,Kume S,Kurokawa K

    更新日期:1991-04-22 00:00:00

  • Expression and functional activity of pro-oxidants and antioxidants in murine heart exposed to acute hypobaric hypoxia.

    abstract::Under hypobaric hypoxia, antioxidant defenses of the heart are stressed by the enhanced production of ROS. Mammalian heart acclimatizes to hypoxia through altered gene expression, which we studied in murine heart exposed to 10h of acute hypobaric hypoxia (AHH), equivalent to 15000ft, using cDNA arrays. Functional clas...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2007.08.044

    authors: Karar J,Dolt KS,Mishra MK,Arif E,Javed S,Pasha MA

    更新日期:2007-10-02 00:00:00

  • An interface point-mutation variant of triosephosphate isomerase is compactly folded and monomeric at low protein concentrations.

    abstract::Wild-type trypanosomal triosephosphate isomerase (wtTIM) is a very tight dimer. The interface residue His-47 of wtTIM has been mutated into an asparagine. Ultracentrifugation data show that this variant (H47N) only dimerises at protein concentrations above 3 mg/ml. H47N has been characterised at a protein concentratio...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(95)00586-x

    authors: Borchert TV,Zeelen JP,Schliebs W,Callens M,Minke W,Jaenicke R,Wierenga RK

    更新日期:1995-07-03 00:00:00

  • Differentiated analysis of the secondary structure of hydrophilic and hydrophobic regions in alpha- and beta-subunits of Na+,K+-ATPase by Raman spectroscopy.

    abstract::Raman spectra of active Na+,K+-ATPase from pig kidney and membrane-bound products of its two-stage trypsinolysis, including alpha-subunit hydrophobic regions as well as the intact beta-subunit and hydrophobic regions of alpha- and beta-subunits, were measured to calculate the secondary structure of hydrophilic and hyd...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(88)80905-0

    authors: Ovchinnikov YuA,Arystarkhova EA,Arzamazova NM,Dzhandzhugazyan KN,Efremov RG,Nabiev IR,Modyanov NN

    更新日期:1988-01-25 00:00:00

  • Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG.

    abstract::(-)-Epigallocatechin-3-O-gallate (EGCG) exhibits anti-tumor activity mediated via the 67-kDa laminin receptor (67LR). In this study, we found that 67LR protein levels are reduced by exposure to low O(2) levels (5%), without affecting the expression of HIF-1α. We also found that EGCG-induced anti-cancer activity is abr...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2012.07.065

    authors: Tsukamoto S,Yamashita S,Kim YH,Kumazoe M,Huang Y,Yamada K,Tachibana H

    更新日期:2012-09-21 00:00:00

  • Free sphingobases induce RBOHD-dependent reactive oxygen species production in Arabidopsis leaves.

    abstract::Sphingolipids are implied in several regulatory processes, including cell death. Levels of the free sphingobase t18:0 (phytosphingosine) increase in Arabidopsis in response to the bacterial pathogen Pseudomonas syringae. To gain information on sphingobase-induced signaling, we determined kinetics of leaf reactive oxyg...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2011.08.016

    authors: Peer M,Bach M,Mueller MJ,Waller F

    更新日期:2011-10-03 00:00:00

  • Location of tolerated insertions/deletions in the structure of the maltose binding protein.

    abstract::In a previous study [(1987) J. Mol. Biol. 194, 663-673], we isolated ten insertion/deletion mutants (indels) of the maltose binding protein for which the maltose binding constant was only a little or not at all affected. In this paper, we have localized these mutations in the recently solved three-dimensional structur...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审

    doi:10.1016/0014-5793(93)81409-s

    authors: Betton JM,Martineau P,Saurin W,Hofnung M

    更新日期:1993-06-28 00:00:00