Overexpression of OsMYB1R1-VP64 fusion protein increases grain yield in rice by delaying flowering time.

abstract：:Mitogen-activated protein (MAP) kinases p42mapk and p44mapk are activated by dual tyrosine and threonine phosphorylation in vivo. Both MAPKs are phosphorylated and activated in vitro by an activator recently identified as a protein-tyrosine/threonine kinase. We have isolated a putative cDNA for a MAP kinase kinase (MA...

journal_title：FEBS letters

authors： Haystead CM,Wu J,Gregory P,Sturgill TW,Haystead TA

更新日期：1993-02-08 00:00:00

abstract：:The conversion of the cellular prion protein into the beta-sheet-rich scrapie prion protein is thought to be the key step in the pathogenesis of prion diseases. To gain insight into this structural conversion, we analyzed the intrinsic structural propensity of the amino acid sequence of the murine prion C-terminal dom...

journal_title：FEBS letters

authors： Jamin N,Coïc YM,Landon C,Ovtracht L,Baleux F,Neumann JM,Sanson A

更新日期：2002-10-09 00:00:00

abstract：:The hemoregulatory peptide PyroGlu-Glu-Asp-Cys-Lys (HP5b), which inhibits myelopoietic colony formation in vitro, is shown to be a sequence motif which is also part of the effector domain of Gi alpha proteins. Out of 8 synthetic peptides with sequence variations of HP5b, those with the closest similarity to the Gi alp...

journal_title：FEBS letters

authors： Laerum OD,Frostad S,Tøn HI,Kamp D

更新日期：1990-08-20 00:00:00

abstract：:The sarcoplasmic reticulum Ca(2+)-ATPase loses hydrolytic activity and the ability to be phosphorylated by Pi following incubation with EDC [1-ethyl-3-(3-dimethylaminopropyl)carbodiimide]. 4 nmol of tempamine per mg SR protein can be coupled to either a glu or an asp side chain through the EDC reaction. Mg2+ protects ...

journal_title：FEBS letters

authors： Coan C,Jakobs P,Ji JY,Murphy AJ

更新日期：1993-11-29 00:00:00

abstract：:tRNAs play a central role in protein translation, acting as the carrier of amino acids. By cloning microRNAs, we unexpectedly obtained some tRNA fragments generated by tRNA cleavage in the anticodon loop. These tRNA fragments are present in many cell lines and different mouse tissues. In addition, various stress condi...

journal_title：FEBS letters

authors： Fu H,Feng J,Liu Q,Sun F,Tie Y,Zhu J,Xing R,Sun Z,Zheng X

更新日期：2009-01-22 00:00:00

abstract：:Excessive βAR stimulation is an independent factor in inducing pathological cardiac hypertrophy. Here, we report miR-145 regulates both expression and localization of GATA6, thereby protecting the heart against cardiomyocyte hypertrophy induced by isoproterenol (ISO). The protective activity of miR-145 was associated ...

journal_title：FEBS letters

authors： Li R,Yan G,Zhang Q,Jiang Y,Sun H,Hu Y,Sun J,Xu B

更新日期：2013-06-19 00:00:00

abstract：:Activation of the formyl peptide chemoattractant receptor (FPCR) of phagocytic cells mobilizes intracellular calcium stores and affects the plasma membrane potential. Affinity crosslinking of FPCR has demonstrated a 60-80 kDa glycoprotein, with core peptide of 32 kDa. It is not known whether functional FPCR is this si...

journal_title：FEBS letters

authors： Murphy PM,Gallin EK,Tiffany HL,Malech HL

更新日期：1990-02-26 00:00:00

abstract：:The minimal functional enzyme unit of Na,K-ATPase consists of an alpha-beta complex. The alpha-subunit bears all functional domains of the enzyme and so far a regulatory role for the beta-subunit in the catalytic cycle has not been established. On the other hand, increasing experimental evidence suggests that the beta...

journal_title：FEBS letters

authors： Geering K

更新日期：1991-07-22 00:00:00

abstract：:The retromer complex is a key element of the endosomal protein sorting machinery that is conserved through evolution and has been shown to play a role in diseases such as Alzheimer's disease and Parkinson's disease. Through sorting various membrane proteins (cargo), the function of retromer complex has been linked to ...

journal_title：FEBS letters

authors： Mukadam AS,Seaman MN

更新日期：2015-09-14 00:00:00

abstract：:The Xenopus laevis oocyte has endogenous sites that bind muscarinic agonists, which have been pharmacologically characterized as M3 and/or M1 receptor subtypes. In order to define the molecular identify of the receptor protein we have analyzed a Xenopus oocyte cDNA library and cloned a 2.9 kb cDNA fragment encoding a ...

journal_title：FEBS letters

authors： Herrera L,Carvallo P,Antonelli M,Olate J

更新日期：1994-09-26 00:00:00

abstract：:Bovine alpha 2-antiplasmin (alpha 2AP) has been purified and partially characterized. The amino acid composition is very similar to that of human alpha 2AP, and the N-terminal (23 residues determined) and reactive site loop sequences (42 residues determined) are highly homologous to those of the human protein. Compare...

journal_title：FEBS letters

authors： Christensen S,Sottrup-Jensen L

更新日期：1992-11-02 00:00:00

abstract：:Microcalorimetric titrations of the two major isotypes of parvalbumin (PA1 and PA2) from bullfrog skeletal muscle with Ca2+ in the presence and absence of Mg2+ have been carried out at 25 degrees C and pH 7.0. The observed enthalpy titration curves were analyzed by the least-squares method. The measured enthalpy chang...

journal_title：FEBS letters

authors： Tanokura M,Yamada K

更新日期：1985-06-03 00:00:00

abstract：:Hematopoietic progenitors have been shown to retain plasticity and switch lineages by appropriate stimuli. However, mature blood cells hardly showed such differentiation plasticity. In this paper, we tried to reprogram mature B cells into erythroid lineage by expressing various hematopoietic transcription factors. Amo...

journal_title：FEBS letters

authors： Sadahira K,Fukuchi Y,Kunimono H,Sakurai M,Ikeda Y,Okamoto S,Nakajima H

更新日期：2012-10-19 00:00:00

abstract：:Botulinum neurotoxins (BoNTs), the causative agent of human botulism, are the most potent naturally occurring toxins known. BoNT/A1, the most studied BoNT, is also used as an important biopharmaceutical. In this study, the biological activity of BoNT/A1 is compared to that of BoNT/A2 using neuronal cell models. The da...

journal_title：FEBS letters

authors： Pier CL,Chen C,Tepp WH,Lin G,Janda KD,Barbieri JT,Pellett S,Johnson EA

更新日期：2011-01-03 00:00:00

abstract：:Covalent dimerization of the adrenocorticotropin fragment ACTH11-24 increases its antagonistic potency on the ACTH-induced steroidogenesis in isolated bovine fasciculata/reticularis cells by 3 orders of magnitude when the C-termini are linked via a 10 A long spacer. This strong potentiation, probably mediated by cross...

journal_title：FEBS letters

authors： Fauchère JL,Rossier M,Capponi A,Vallotton MB

更新日期：1985-04-22 00:00:00

abstract：:The involvement of Ca(2+) in the response to high Mn(2+), Co(2+), Ni(2+), Cu(2+), Zn(2+), Cd(2+), and Hg(2+) was investigated in Saccharomyces cerevisiae. The yeast cells responded through a sharp increase in cytosolic Ca(2+) when exposed to Cd(2+), and to a lesser extent to Cu(2+), but not to Mn(2+), Co(2+), Ni(2+), ...

journal_title：FEBS letters

authors： Ruta LL,Popa VC,Nicolau I,Danet AF,Iordache V,Neagoe AD,Farcasanu IC

更新日期：2014-08-25 00:00:00

abstract：:Human T-cell leukemia and bovine leukemia viruses have a potential transforming gene, termed X. In addition to the major open reading frame known to encode a functional protein, the X gene harbors another short open reading frame which overlaps this major one. Both of these open reading frames are found on a single sp...

journal_title：FEBS letters

authors： Sagata N,Yasunaga T,Ikawa Y

更新日期：1985-11-11 00:00:00

abstract：:Spectral variants of the green fluorescent protein (GFP) have been extensively used as reporters to image molecular interactions in living cells by fluorescence resonance energy transfer (FRET). However, those GFP variants which are the most efficient donor acceptor pairs for FRET measurements show a high degree of sp...

journal_title：FEBS letters

authors： Zimmermann T,Rietdorf J,Girod A,Georget V,Pepperkok R

更新日期：2002-11-06 00:00:00

abstract：:Several components of translation, e.g. eIF4E and PKR, are implicated in cancer. The e-subunit (p48) of mammalian initiation factor 3 is encoded by the Int6 gene, a common site for integration of the mouse mammary tumor virus genome, leading to the production of a truncated eukaryotic initiation factor-3e (eIF3e). Sta...

journal_title：FEBS letters

authors： Mayeur GL,Hershey JW

更新日期：2002-03-06 00:00:00

abstract：:A peroxidase with stability, chromatographic and immunoreactive properties similar to that of bovine lactoperoxidase has been partly purified from human colostrum. Hydrophobic interaction chromatography on Phenyl-Sepharose C1-4B gave a 10-fold purification with an apparent recovery of about 45%. The enzyme was quantit...

journal_title：FEBS letters

authors： Langbakk B,Flatmark T

更新日期：1984-09-03 00:00:00

abstract：:Blood flukes of the genus Schistosoma currently infect millions of people in tropical and subtropical countries. An enzyme playing a major role in hemoglobin (Hb) degradation by Schistosoma mansoni has been cloned and shown to be highly similar to the human cathepsin D aspartyl proteinase, although presenting a distin...

journal_title：FEBS letters

authors： Silva FP Jr,Ribeiro F,Katz N,Giovanni-De-Simone S

更新日期：2002-03-13 00:00:00

abstract：:We previously have shown that the overexpression of phospholipase C-gamma1 (PLC-gamma1) in rat 3Y1 fibroblasts results in malignant transformation (Chang, J.-S., Noh, D.Y., Park, I.A., Kim, M;.J., Song, H., Ryu, S.H. and Suh, P.-G. (1997) Cancer Res. 57, 5465-5468). The transformed cells, which initially are in an elo...

journal_title：FEBS letters

authors： Chang JS,Iwashita S,Lee YH,Kim MJ,Ryu SH,Suh PG

更新日期：1999-10-22 00:00:00

abstract：:In the present study we have examined the levels and phosphorylation state of the insulin receptor and insulin receptor substrate 1 (IRS-1) as well as the association between IRS-1 and phosphatidylinositol 3-kinase (PI 3-kinase) in the liver and muscle of rats treated with glucagon. There was a decrease in the insulin...

journal_title：FEBS letters

authors： Saad MJ,Hartmann LG,de Carvalho DS,Galoro CA,Brenelli SL,Carvalho CR

更新日期：1995-08-14 00:00:00

abstract：:The study of the three-dimensional organization of chromatin has recently gained much focus in the context of novel techniques for detecting genome-wide contacts using next-generation sequencing. These chromosome conformation capture-based methods give a deep topological insight into the architecture of the genome ins...

journal_title：FEBS letters

authors： Hofmann A,Heermann DW

更新日期：2015-10-07 00:00:00

abstract：:Hyperthyroid mitochondria show an increased Km and Vmax in the high affinity phase of cytochrome oxidase kinetics. During inhibitor titrations, cytochrome c shows a different redox behaviour in hyperthyroid with respect to protonophore-treated euthyroid mitochondria. The observations are discussed in terms of a differ...

journal_title：FEBS letters

authors： Schmehl I,Luvisetto S,Canton M,Gennari F,Azzone GF

更新日期：1995-11-20 00:00:00

abstract：:Besides its canonical function of catalyzing the formation of telomeric repeats, many groups have recently reported non-canonical functions of hTERT in particular, and telomerase in general. Regulating transcription is the central basis of non-canonical functions of telomerase. However, unlike reverse transcriptase ac...

journal_title：FEBS letters

authors： Akıncılar SC,Low KC,Liu CY,Yan TD,Oji A,Ikawa M,Li S,Tergaonkar V

更新日期：2015-04-13 00:00:00

abstract：:Autophagy is an evolutionarily conserved stress response that promotes the lysosomal degradation of intracellular components. The bone marrow stromal cell-derived growth inhibitor (BDGI) functions as a stress sensor which is upregulated by oxidative stress and DNA damage. However, the role of BDGI in autophagic respon...

journal_title：FEBS letters

authors： Zhang J,Wang L,Xu J,Tang Y,Huang B,Chen Z,Zhang T,Shen HM,Wu Y,Xia D

更新日期：2020-04-01 00:00:00

abstract：:A monoclonal antibody (Z1H01) for an oligopeptide carrying an azobenzene group, was prepared under conditions where the azobenzene group is in the trans form. The antibody bound the hapten peptide effectively when the hapten peptide is in the trans form (K = 5 x 10(7) M-1), but the antibody released the hapten under i...

journal_title：FEBS letters

authors： Harada M,Sisido M,Hirose J,Nakanishi M

更新日期：1991-07-29 00:00:00

abstract：:Coenzyme A ligases play an important role in metabolism by catalyzing the activation of carboxylic acids. In this study we describe the synthesis of aminoacyl-coenzyme As (CoAs) catalyzed by a CoA ligase from Penicillium chrysogenum. The enzyme accepted medium-chain length fatty acids as the best substrates, but the p...

journal_title：FEBS letters

authors： Koetsier MJ,Jekel PA,Wijma HJ,Bovenberg RA,Janssen DB

更新日期：2011-03-23 00:00:00

abstract：:We used cDNA microarray to identify transforming growth factor beta (TGF-beta) responsive target genes during osteoblast development and found that nephronectin (Npnt) is one such gene that is significantly down-regulated. Here we report the role of TGF-beta in regulating Npnt-mediated osteoblast differentiation. We f...

journal_title：FEBS letters

authors： Fang L,Kahai S,Yang W,He C,Seth A,Peng C,Yang BB

更新日期：2010-07-02 00:00:00