Abstract:
:Covalent dimerization of the adrenocorticotropin fragment ACTH11-24 increases its antagonistic potency on the ACTH-induced steroidogenesis in isolated bovine fasciculata/reticularis cells by 3 orders of magnitude when the C-termini are linked via a 10 A long spacer. This strong potentiation, probably mediated by cross-linking of the receptors, was shown to be dependent on the point of attachment of the monomeric fragment to the spacer, thus providing information about the position of the binding site in the hormonal segment and about the distance of the receptors on the cell surface.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fauchère JL,Rossier M,Capponi A,Vallotton MBdoi
10.1016/0014-5793(85)80794-8subject
Has Abstractpub_date
1985-04-22 00:00:00pages
283-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(85)80794-8journal_volume
183pub_type
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