Abstract:
:Several components of translation, e.g. eIF4E and PKR, are implicated in cancer. The e-subunit (p48) of mammalian initiation factor 3 is encoded by the Int6 gene, a common site for integration of the mouse mammary tumor virus genome, leading to the production of a truncated eukaryotic initiation factor-3e (eIF3e). Stable expression of a truncated eIF3e in NIH 3T3 cells causes malignant transformation by four criteria: foci formation; anchorage independent growth; accelerated growth; and lack of contact inhibition. Stable expression of full-length eIF3e does not cause transformation. The truncated eIF3e also inhibits the onset of apoptosis caused by serum starvation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mayeur GL,Hershey JWdoi
10.1016/s0014-5793(02)02307-4keywords:
subject
Has Abstractpub_date
2002-03-06 00:00:00pages
49-54issue
1eissn
0014-5793issn
1873-3468pii
S0014579302023074journal_volume
514pub_type
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