Abstract:
:We show that anthocyanins can function as potent inhibitors of the formation of nitrated tyrosine in vitro, and clarified how pelargonidin (Pel), which has a mono-hydroxyl group on the B-ring, can scavenge peroxynitrite (ONOO(-)) by detection of the reaction products. Pel was reacted with ONOO(-), then the reaction mixture was analyzed using high-performance liquid chromatography (HPLC). The HPLC analyses showed two novel peaks assumed to be the reaction products. Based on the instrumental analyses, the reaction products were identified as p-hydroxybenzoic acid and 4-hydroxy-3-nitrobenzoic acid. Pel can protect tyrosine from undergoing nitration through the formation of p-hydroxybenzoic acid and 4-hydroxy-3-nitrobenzoic acid.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tsuda T,Kato Y,Osawa Tdoi
10.1016/s0014-5793(00)02150-5keywords:
subject
Has Abstractpub_date
2000-11-10 00:00:00pages
207-10issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(00)02150-5journal_volume
484pub_type
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