BMP signaling in vascular diseases.

Abstract:

:Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. BMPs are multifunctional regulators of development and tissue homeostasis and they were initially characterized as inducers of bone regeneration. Genetic studies in humans and mice showed that perturbations in BMP signaling lead to various diseases, such as skeletal diseases, vascular diseases and cancer. Mutations in BMP type II receptor and BMP type I receptor/activin receptor-like kinase 1 have been linked to pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, respectively. BMPs have also been implicated in promoting vascular calcification and tumor angiogenesis. In this review we discuss the role of BMP signaling in vascular diseases and the value of BMP signaling as a vascular disease marker or a therapeutic target.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Cai J,Pardali E,Sánchez-Duffhues G,ten Dijke P

doi

10.1016/j.febslet.2012.04.030

subject

Has Abstract

pub_date

2012-07-04 00:00:00

pages

1993-2002

issue

14

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(12)00319-5

journal_volume

586

pub_type

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