Abstract:
:Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. BMPs are multifunctional regulators of development and tissue homeostasis and they were initially characterized as inducers of bone regeneration. Genetic studies in humans and mice showed that perturbations in BMP signaling lead to various diseases, such as skeletal diseases, vascular diseases and cancer. Mutations in BMP type II receptor and BMP type I receptor/activin receptor-like kinase 1 have been linked to pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, respectively. BMPs have also been implicated in promoting vascular calcification and tumor angiogenesis. In this review we discuss the role of BMP signaling in vascular diseases and the value of BMP signaling as a vascular disease marker or a therapeutic target.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Cai J,Pardali E,Sánchez-Duffhues G,ten Dijke Pdoi
10.1016/j.febslet.2012.04.030subject
Has Abstractpub_date
2012-07-04 00:00:00pages
1993-2002issue
14eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00319-5journal_volume
586pub_type
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