Abstract:
:The amplification of hTERT was detected in glioma tissues, although telomerase activity was not always found within these specimens. The aim of this study was to correlate the level of hTERT transcription with telomerase activity in two glioma age groups. hTERT was significantly transcribed at similar copy numbers in both age groups. However, these mRNAs translated to telomerase in 100% of the young compared to only 25% of the older patients. While hTERT transcription correlated directly to telomerase protein level and activity, as well as longer telomeres in the young group, such correlations were missing in the older group.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Shervington A,Patel Rdoi
10.1016/j.febslet.2008.04.027subject
Has Abstractpub_date
2008-05-28 00:00:00pages
1707-10issue
12eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00345-1journal_volume
582pub_type
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