Abstract:
:The present study provides the first evidence that the abundance of catalytic alpha1-subunit of Na,K-ATPase increases in the course of T cell blast transformation. Immunodepressant cyclosporin A at anti-proliferative doses diminished the induction of alpha1 protein in activated lymphocytes. Furthermore, in competent T cells, IL-2 increases both the transport activity of Na/K pump and the content of Na,K-ATPase alpha1 protein in a time-dependent manner. A correlation was found between the long-term elevation in ouabain-sensitive Rb influxes and the increase in alpha1 protein content in late activated T cells. These results suggest that (1) the increased expression of Na,K-ATPase proteins underlie the cell cycle-dependent upregulation of ion pump during T cell transformation, and (2) IL-2 is involved in the regulated expression of Na,K-ATPase in human lymphocytes.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Marakhova I,Karitskaya I,Aksenov N,Zenin V,Vinogradova Tdoi
10.1016/j.febslet.2005.03.096keywords:
subject
Has Abstractpub_date
2005-05-23 00:00:00pages
2773-80issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00468-0journal_volume
579pub_type
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