Activation of oxidative stress response by hydroxyl substituted chalcones and cyclic chalcone analogues in mitochondria.

Abstract:

:We investigated the effect of hydroxyl substituted chalcone (1a) and some chalcone analogues (1b-d) on isolated rat liver mitochondria to gain new insights into the cytotoxic mechanism of these compounds. We observed an inhibitory effect on phosphorylation and the partial uncoupling of compounds 1a and 1d. Increased radical generation and possible covalent interaction of the compounds with cellular thiols resulted in glutathione (GSH) depletion and modulation of the investigated mitochondrial activities. Disruption of interconnected mechanisms as electron transport chain and energetic metabolism, ROS production and insufficiency of antioxidant defensive system could lead to induction of cell death.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Guzy J,Vasková-Kubálková J,Rozmer Z,Fodor K,Mareková M,Poskrobová M,Perjési P

doi

10.1016/j.febslet.2009.11.098

subject

Has Abstract

pub_date

2010-02-05 00:00:00

pages

567-70

issue

3

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(09)01045-X

journal_volume

584

pub_type

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