Abstract:
:We investigated the effect of hydroxyl substituted chalcone (1a) and some chalcone analogues (1b-d) on isolated rat liver mitochondria to gain new insights into the cytotoxic mechanism of these compounds. We observed an inhibitory effect on phosphorylation and the partial uncoupling of compounds 1a and 1d. Increased radical generation and possible covalent interaction of the compounds with cellular thiols resulted in glutathione (GSH) depletion and modulation of the investigated mitochondrial activities. Disruption of interconnected mechanisms as electron transport chain and energetic metabolism, ROS production and insufficiency of antioxidant defensive system could lead to induction of cell death.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Guzy J,Vasková-Kubálková J,Rozmer Z,Fodor K,Mareková M,Poskrobová M,Perjési Pdoi
10.1016/j.febslet.2009.11.098subject
Has Abstractpub_date
2010-02-05 00:00:00pages
567-70issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(09)01045-Xjournal_volume
584pub_type
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