Abstract:
:We screened active compounds from natural marine products able to increase PPARalpha/gamma transcriptional activity. Sargaquinoic acid (SQA) and sargahydroquinoic acid (SHQA) from Sargassum yezoense were identified as novel PPARalpha/gamma dual agonists. The binding affinity of SQA with PPARgamma was higher than that of the specific PPARgamma agonist troglitazone, leading to an activation of PPARgamma transcriptional activity. In parallel, treatment of 3T3-L1 cells with SQA and SHQA led to an increase in adipocyte differentiation and increased expression of adipogenic marker genes such as aP2, PPARgamma, resistin, adiponectin, C/EBPalpha and Glut4. Collectively, our data suggest that SQA and SHQA are novel PPARalpha/gamma dual agonists and may be beneficial for reducing insulin resistance through regulation of adipogenesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kim SN,Choi HY,Lee W,Park GM,Shin WS,Kim YKdoi
10.1016/j.febslet.2008.09.011subject
Has Abstractpub_date
2008-10-15 00:00:00pages
3465-72issue
23-24eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00744-8journal_volume
582pub_type
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