Abstract:
:Adiponectin whose systemic levels are reduced in obesity-related diseases ameliorates insulin sensitivity and regulates biological processes like apoptosis, proliferation, migration and inflammation. Adiponectin binds to adiponectin receptors, AdipoR1 and AdipoR2, which are ubiquitously expressed. Clathrin-dependent endocytosis of AdipoR1 and adiponectin has been demonstrated to modulate adiponectin bioactivity. Recently, APPL1 has been identified as an AdipoR1 and AdipoR2 binding protein. Furthermore, activated protein kinase C1, endoplasmic reticulum protein 46 and protein kinase CK2β subunit form a complex with AdipoR1. This review summarizes recent studies exploiting heterologous expression of adiponectin receptors in yeast, and the type and function of the recently described adiponectin receptor associated proteins.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Buechler C,Wanninger J,Neumeier Mdoi
10.1016/j.febslet.2010.09.035subject
Has Abstractpub_date
2010-10-22 00:00:00pages
4280-6issue
20eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00772-6journal_volume
584pub_type
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