Abstract:
:The maximal activities of the key glycolytic enzymes hexokinase and 6-phosphofructokinase, were reduced in brown adipose tissue in db/db mice compared to their lean littermates. Treatment of db/db mice with the thermogenic beta-adrenoceptor agonist, BRL 26830, restored normoglycaemia. The only significant increase in activity of hexokinase and 6-phosphofructokinase in the BRL 26830-treated db/db mice occurred in brown adipose tissue where the total tissue activity increased 10- and 11-fold respectively. These changes together with increased 2-deoxyglucose uptake in vivo suggest that brown adipose tissue can play a quantitatively important role in the removal of glucose from the blood.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Young P,Cawthorne MA,Levy AL,Wilson Kdoi
10.1016/0014-5793(84)80903-5subject
Has Abstractpub_date
1984-10-15 00:00:00pages
16-20issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(84)80903-5journal_volume
176pub_type
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