Abstract:
:A mouse somatostatin (SS) receptor cDNA was cloned from neuroblastoma x glioma (NG108-15) cells. The sequence is almost identical to that of the mouse SSTR2 receptor [(1992) Proc. Natl. Acad. Sci. USA 89, 251)] but lacks about 300 nucleotides between transmembrane domain VII and the C-terminus. This spliced variant of SSTR2 (designated SSTR2B) encodes a protein which is 23 residues shorter than that predicted from the SSTR2 sequence, and differs in 15 amino acids at the C-terminus. mRNA corresponding to SSTR2B occurs in mouse tissues in higher abundance than that of SSTR2. SSTR2B binds SS peptides with high affinity when expressed in mammalian cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Vanetti M,Kouba M,Wang X,Vogt G,Höllt Vdoi
10.1016/0014-5793(92)81122-3keywords:
subject
Has Abstractpub_date
1992-10-26 00:00:00pages
290-4issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(92)81122-3journal_volume
311pub_type
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