The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site.

Abstract:

:Three proteins of the mitochondrial inner membrane are known that are essential for the viability of yeast and seem to be involved in import of preproteins; the integral membrane proteins MIM17 and MIM23 and the peripheral membrane protein MIM44, MIM17 and MIM23 are homologous to each other in their hydrophobic domain, expose their termini to the intermembrane space, and span the inner membrane up to four times, each. A preprotein in transit across the mitochondrial membrane is specifically cross-linked to MIM17, MIM23, MIM44, and matrix hsp70. We conclude that MIM17 and MIM23 are integral parts of a preprotein translocation channel and cooperate with MIM44 and hsp70 at the same protein import site.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Kübrich M,Keil P,Rassow J,Dekker PJ,Blom J,Meijer M,Pfanner N

doi

10.1016/0014-5793(94)00670-9

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

222-8

issue

2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(94)00670-9

journal_volume

349

pub_type

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