Abstract:
:Three proteins of the mitochondrial inner membrane are known that are essential for the viability of yeast and seem to be involved in import of preproteins; the integral membrane proteins MIM17 and MIM23 and the peripheral membrane protein MIM44, MIM17 and MIM23 are homologous to each other in their hydrophobic domain, expose their termini to the intermembrane space, and span the inner membrane up to four times, each. A preprotein in transit across the mitochondrial membrane is specifically cross-linked to MIM17, MIM23, MIM44, and matrix hsp70. We conclude that MIM17 and MIM23 are integral parts of a preprotein translocation channel and cooperate with MIM44 and hsp70 at the same protein import site.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kübrich M,Keil P,Rassow J,Dekker PJ,Blom J,Meijer M,Pfanner Ndoi
10.1016/0014-5793(94)00670-9subject
Has Abstractpub_date
1994-08-01 00:00:00pages
222-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(94)00670-9journal_volume
349pub_type
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