Abstract:
:Lysosomal/phagosomal membranes of mammalian cells are coated by highly conserved glycoproteins (lamps) that are thought to protect the membranes from degradation. Interestingly, we identified an amino acid sequence in human lamp-1 characteristic of a cleavage site for the Neisseria gonorrhoeae IgA1 protease. Furthermore, gonococci are detected in h-lamp-1-positive vacuoles after their uptake by professional phagocytes and epithelial cells. Here we demonstrate cleavage of glycosylated h-lamp-1 by the secreted gonococcal IgA1 protease. The cleavage was observed with h-lamp-1 purified from epithelial cells but not from professional phagocytes. The biological role of lamp-1 cleavage by the gonococcal protease is discussed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hauck CR,Meyer TFdoi
10.1016/s0014-5793(97)00163-4subject
Has Abstractpub_date
1997-03-17 00:00:00pages
86-90issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(97)00163-4journal_volume
405pub_type
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