Abstract:
:Systemic AA-amyloidosis is a complication of chronic inflammatory diseases and the fibril protein AA derives from the acute phase reactant serum AA. AA-amyloidosis can be induced in mice by an inflammatory challenge. The lag phase before amyloid develops can be dramatically shortened by administration of a small amount of amyloid fibrils. Systemic AA-amyloidosis is transmissible in mice and may be so in humans. Since transmission can cross species barriers it is possible that AA-amyloidosis can be induced by amyloid in food, e.g. foie gras. In mice, development of AA-amyloidosis can also be accelerated by other components with amyloid-like properties. A new possible risk factor may appear with synthetically made fibrils from short peptides, constructed for tissue repair.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Westermark GT,Westermark Pdoi
10.1016/j.febslet.2009.04.026subject
Has Abstractpub_date
2009-08-20 00:00:00pages
2685-90issue
16eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00310-Xjournal_volume
583pub_type
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