Serum amyloid A and protein AA: molecular mechanisms of a transmissible amyloidosis.

Abstract:

:Systemic AA-amyloidosis is a complication of chronic inflammatory diseases and the fibril protein AA derives from the acute phase reactant serum AA. AA-amyloidosis can be induced in mice by an inflammatory challenge. The lag phase before amyloid develops can be dramatically shortened by administration of a small amount of amyloid fibrils. Systemic AA-amyloidosis is transmissible in mice and may be so in humans. Since transmission can cross species barriers it is possible that AA-amyloidosis can be induced by amyloid in food, e.g. foie gras. In mice, development of AA-amyloidosis can also be accelerated by other components with amyloid-like properties. A new possible risk factor may appear with synthetically made fibrils from short peptides, constructed for tissue repair.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Westermark GT,Westermark P

doi

10.1016/j.febslet.2009.04.026

subject

Has Abstract

pub_date

2009-08-20 00:00:00

pages

2685-90

issue

16

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(09)00310-X

journal_volume

583

pub_type

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