Abstract:
:In the present study we have examined the levels and phosphorylation state of the insulin receptor and insulin receptor substrate 1 (IRS-1) as well as the association between IRS-1 and phosphatidylinositol 3-kinase (PI 3-kinase) in the liver and muscle of rats treated with glucagon. There was a decrease in the insulin-stimulated receptor and IRS-1 phosphorylation levels which was paralleled by a reduced association between IRS-1 and PI 3-kinase in vivo in the liver and muscle of glucagon-treated rats. These observations suggest that glucagon, probably acting through cAMP, may impair insulin signaling in the three early steps in insulin action after binding.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Saad MJ,Hartmann LG,de Carvalho DS,Galoro CA,Brenelli SL,Carvalho CRdoi
10.1016/0014-5793(95)00809-nsubject
Has Abstractpub_date
1995-08-14 00:00:00pages
131-4issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(95)00809-Njournal_volume
370pub_type
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