Abstract:
:The transdifferentiation of hepatic stellate cells into myofibroblast-like cells and the proliferation of the transdifferentiated cells are controlled by TGF-beta1. Little is known about the intracellular signal transducers of TGF-beta1. In this paper we show that in cultured hepatic stellate cells TGF-beta1 induces activation of Ras, Raf-1, MEK and MAPK p42 and p44. The activation of MAPK depends on the activation of MEK. Our data exclude that the observed effects are mediated by a bFGF or PDGF autocrine loop.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Reimann T,Hempel U,Krautwald S,Axmann A,Scheibe R,Seidel D,Wenzel KWdoi
10.1016/s0014-5793(97)00024-0subject
Has Abstractpub_date
1997-02-10 00:00:00pages
57-60issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(97)00024-0journal_volume
403pub_type
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