Abstract:
:5-(1-Azidovinyl)-2'-deoxyuridine (AzVDU) and a series of 5-[1-azido-2-halogenoethyl]-derivatives of beta-D-arabinofuranosyluracil (AU) proved markedly inhibitory to the replication of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV), but not thymidine kinase (TK)-deficient HSV-1 and VZV strains. None of the compounds were cytostatic. However, AzVDU, but not the 5-[1-azido-2-halogenoethyl]-AU derivatives became highly cytostatic against HSV-1 and HSV-2 TK gene-transfected FM3A tumor cells. The molecular target for the cytostatic effect of AzVDU proved to be thymidylate synthase. Short exposure of AzVDU-treated FM3A TK-/HSV-1 TK+ cells to irradiation at lambda = 254 nm enhanced the cytostatic activity of AzVDU by 5-fold.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Balzarini J,Andrei G,Kumar R,Knaus EE,Wiebe LI,De Clercq Edoi
10.1016/0014-5793(95)00994-ksubject
Has Abstractpub_date
1995-10-02 00:00:00pages
41-4issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(95)00994-Kjournal_volume
373pub_type
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