Abstract:
:Acetaldehyde (1-20 mM) was metabolized at high rates and in a dose-dependent manner in isolated human and baboon kidney-cortex tubules. Acetaldehyde removal was accompanied by a large accumulation of acetate in both human and baboon tubules. By contrast, a large synthesis of ethanol was observed only in baboon tubules. Consistent with the latter finding, ethanol was found to be metabolized at significant rates in baboon but not human tubules. In the tubules from both species, a significant fraction of the acetaldehyde removed was also completely oxidized to CO2 and H2O. These results suggest that, in both man and baboon, the kidneys participate in the in vivo metabolism of acetaldehyde; they also suggest that, in contrast with the human kidneys, the baboon kidneys contribute to the detoxication of circulating ethanol.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Michoudet C,Baverel Gdoi
10.1016/0014-5793(87)80767-6subject
Has Abstractpub_date
1987-05-25 00:00:00pages
113-7issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(87)80767-6journal_volume
216pub_type
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