Abstract:
:Transections of the entorhinal afferent fibers to hippocampus, perforant path (PP), result in the denervation in specific hippocampal subregions, which is followed by a series of plastic events including axon sprouting and reactive synaptogenesis. Many growth-associated molecules are thought to participate in these events. In the present study, we proved the upregulation of ephrin-A2 in the denervated areas of the ipsilateral hippocampus following PP transections. Interestingly, when the elevation of ephrin-A2 reached the maximum axon sprouting in the denervated areas almost finished, implying the possible inhibitory effect of ephrin-A2 on sprouting. In addition, ephrin-A2 expression was observed in synapses during reactive synaptogenesis, suggesting that this molecule might also be implicated in the formation and maturation of synapses in the denervated areas.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wang Y,Ni ZM,Zhou CFdoi
10.1016/j.febslet.2005.01.007keywords:
subject
Has Abstractpub_date
2005-02-14 00:00:00pages
1055-60issue
5eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00050-5journal_volume
579pub_type
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