Low-temperature microRNA expression in the painted turtle, Chrysemys picta during freezing stress.

Abstract:

:Natural freeze tolerance depends on cellular adaptations that address the multiple stresses imposed on cells during freezing. These adaptations preserve viability by suppressing energy-expensive cell processes in the frozen state. In this study, we explore the freeze-responsive expression of microRNA in hatchling painted turtles exposed to 20 h freezing. Furthermore, we also explore the possibility of unique temperature-sensitive microRNA targeting programs that aid in adapting turtles for survival in the frozen state. Interestingly, two freeze-responsive 'cryo-miRs' (cpm-miR-16 and cpm-miR-21) were found to have unique low-temperature mRNA targets enriched in biological processes that are known to be part of the stress response.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Biggar KK,Storey KB

doi

10.1016/j.febslet.2015.10.026

subject

Has Abstract

pub_date

2015-11-30 00:00:00

pages

3665-70

issue

23

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(15)00950-3

journal_volume

589

pub_type

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