Abstract:
:Natural freeze tolerance depends on cellular adaptations that address the multiple stresses imposed on cells during freezing. These adaptations preserve viability by suppressing energy-expensive cell processes in the frozen state. In this study, we explore the freeze-responsive expression of microRNA in hatchling painted turtles exposed to 20 h freezing. Furthermore, we also explore the possibility of unique temperature-sensitive microRNA targeting programs that aid in adapting turtles for survival in the frozen state. Interestingly, two freeze-responsive 'cryo-miRs' (cpm-miR-16 and cpm-miR-21) were found to have unique low-temperature mRNA targets enriched in biological processes that are known to be part of the stress response.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Biggar KK,Storey KBdoi
10.1016/j.febslet.2015.10.026subject
Has Abstractpub_date
2015-11-30 00:00:00pages
3665-70issue
23eissn
0014-5793issn
1873-3468pii
S0014-5793(15)00950-3journal_volume
589pub_type
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