Abstract:
:It was recently shown that there is a predominance of phase 1 introns near the cleavage site of signal peptides encoded by human genes. It was suggested that this biased distribution was due to intron insertion at AGmid R:G proto-splice sites. However, we found that there is no disproportional excess of AGmid R:G that would support insertion at proto-splice sites. In fact, all nGmid R:G sites are enriched in the vicinity of the cleavage site. Additional analyses support an alternative scenario in which exon-shuffling is largely responsible for such excess of phase 1 introns.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Vibranovski MD,Sakabe NJ,de Souza SJdoi
10.1016/j.febslet.2006.01.094keywords:
subject
Has Abstractpub_date
2006-03-06 00:00:00pages
1621-4issue
6eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00183-9journal_volume
580pub_type
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