Abstract:
:In the current work, we report that specific inhibition of Janus tyrosine kinase (JAK3) via NC1153 induces apoptosis of certain leukemia/lymphoma cell lines. Affymetrix microarray profiling following NC1153 treatment unveiled JAK3 dependent survival modulating pathways (p53, TGF-beta, TNFR and ER stress) in Kit225 cells. IL-2 responsive NC1153 target genes were regulated in human JAK3 positive, but not in JAK3 negative lymphoid tumor cells. Moreover, primary lymphoma samples revealed that a number of these genes were reciprocally regulated during disease progression and JAK3 inhibition suggesting that downstream targets of JAK3 could be exploited in the development of novel cancer treatment regimes.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nagy ZS,Ross JA,Rodriguez G,Bader J,Dimmock J,Kirken RAdoi
10.1016/j.febslet.2010.02.071subject
Has Abstractpub_date
2010-04-16 00:00:00pages
1515-20issue
8eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00193-6journal_volume
584pub_type
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