Abstract:
:Several analogues of heat-stable enterotoxins (STh and STp) produced by enterotoxigenic Escherichia coli were synthesized. Peptides (STh[6-18] and STp[5-17]) consisting of 13 amino acid residues from the Cys residue near the N-terminus to the Cys residue near the C-terminus and linked by three disulfide bonds had the same biological and immunological properties as native STh and STp, respectively. The results indicated that the sequence with the 13 amino acid residues and three disulfide linkages is essential for full biological activity of ST.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Yoshimura S,Ikemura H,Watanabe H,Aimoto S,Shimonishi Y,Hara S,Takeda T,Miwatani T,Takeda Ydoi
10.1016/0014-5793(85)81129-7subject
Has Abstractpub_date
1985-02-11 00:00:00pages
138-42issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(85)81129-7journal_volume
181pub_type
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