Abstract:
:MM-1 has been reported to repress the E-box-dependent transcription activity of c-Myc by recruiting histone deacetylase 1 complex via TIF1beta/KAP1. In this study, to identify target genes for c-Myc-MM-1-TIF1beta, we established rat-1 cells harboring the dominant-negative form of TIF1beta to abrogate the pathway from TIF1beta to MM-1-c-Myc. This cell line, in which transcription activity of c-Myc was activated, was found to be tumorigenic. By DNA-microarray analysis of this cell line, expression and promoter activity of the c-fms oncogene were found to be upregulated. Of the two promoters, pE1 and pE2, in the c-fms gene, pE1 promoter activity was found to be activated in an E-box-dependent manner.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Satou A,Hagio Y,Taira T,Iguchi-Ariga SM,Ariga Hdoi
10.1016/j.febslet.2004.07.034keywords:
subject
Has Abstractpub_date
2004-08-13 00:00:00pages
211-5issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579304009159journal_volume
572pub_type
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