Abstract:
:Glutamate uptake by rat hepatocytes in primary monolayer culture was found to be mediated by a Na+-independent and by two Na+-dependent transport systems of high and low affinity. Inhibition studies with cysteate and other model amino acids rules out the participation of the neutral amino acid transport systems A, ASC, and N and revealed that the Na+-dependent agencies represent unequivocally anionic transport systems. Na+-dependent uptake of glutamate in isolated hepatocytes was slow compared to the Na+-independent portion, but increased spontaneously during cultivation. In the presence of dexamethasone it was stimulated about 10-fold at the second day of cultivation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gebhardt R,Mecke Ddoi
10.1016/0014-5793(83)81024-2subject
Has Abstractpub_date
1983-09-19 00:00:00pages
275-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(83)81024-2journal_volume
161pub_type
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