Abstract:
:A new peptide, Tc1, containing only 23 amino acids closely packed by three disulfide bridges was isolated from the Amazonian scorpion Tityus cambridgei. It blocks reversibly the Shaker B K(+)-channels with a K(d) of 65 nM and displaces binding of noxiustoxin to mouse brain synaptosome membranes. It is the shortest known peptide from scorpion venom that recognizes K(+)-channels and constitutes a new structural subfamily of toxin, classified as alphaKTx 13.1.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Batista CV,Gómez-Lagunas F,Lucas S,Possani LDdoi
10.1016/s0014-5793(00)02253-5keywords:
subject
Has Abstractpub_date
2000-12-08 00:00:00pages
117-20issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(00)02253-5journal_volume
486pub_type
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