Abstract:
:Hepatitis B virus X protein is a major factor in the HBV-induced disease developments. Stromal cell-derived factor-1 is a small cytokine that is strongly chemotactic for lymphocytes. We explored the role of HBx on recruitment of HBV-induced virus-nonspecific immune cells into liver. Immune cell recruitment and SDF-1 expression level significantly increased in livers of HBx-transgenic mice and X-box binding protein-1 significantly increased SDF-1 gene expression. Finally, we confirmed that immune cell recruitment into liver tissues of HBx-TG mice was diminished by a chemokine receptor antagonist. Therefore, HBx increases ER stress-dependent SDF-1 expression and induces HBV-induced immune cell recruitment into liver.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Cho HK,Kim SY,Seong JK,Cheong Jdoi
10.1016/j.febslet.2014.01.017subject
Has Abstractpub_date
2014-03-03 00:00:00pages
733-9issue
5eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00043-Xjournal_volume
588pub_type
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