Abstract:
:This study investigates to what extent the expression of the slow myosin heavy chain (MyHCI) isoform and the slow type sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) isoform are co-regulated in fibers of regenerating skeletal soleus muscle. Both overexpression of cain, a calcineurin inhibitor, or partial tenotomy prevented the expression of MyHCI but left SERCA2a expression unaffected in fibers of regenerating soleus muscles. These data complement those from different experimental models and clearly show that the expression of MyHCI and SERCA2a--the major proteins mediating, respectively, the slow type of contraction and relaxation--are not coregulated in regenerating soleus muscle.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Zádor E,Fenyvesi R,Wuytack Fdoi
10.1016/j.febslet.2004.12.061keywords:
subject
Has Abstractpub_date
2005-01-31 00:00:00pages
749-52issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00017-7journal_volume
579pub_type
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