Inhibition of ICE-family cysteine proteases rescues murine lymphocytes from lipoxygenase inhibitor-induced apoptosis.

Abstract:

:Two lipophilic derivatives of caffeic acid which inhibit lipoxygenase, caffeic acid phenethyl ester (CAPE) and N,N'-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)-isourea (DCHCU), reduced the proliferative response of murine splenocytes to concanavalin A in vitro. Both CAPE and DCHCU induced apoptosis in murine thymocyte cultures as verified by flow cytometry and by visualisation of DNA with acridine orange staining. CAPE-induced apoptosis was inhibited by z-VAD-fmk, an inhibitor of the interleukin-1beta-converting enzyme family of cysteine proteases. We suggest that the lipoxygenase pathway of arachidonic acid metabolism plays a role in regulating lymphocyte responses such as proliferation and apoptosis.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Mirzoeva OK,Yaqoob P,Knox KA,Calder PC

doi

10.1016/0014-5793(96)01111-8

subject

Has Abstract

pub_date

1996-11-04 00:00:00

pages

266-70

issue

2-3

eissn

0014-5793

issn

1873-3468

pii

0014-5793(96)01111-8

journal_volume

396

pub_type

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