Abstract:
:Cytotoxic effects were observed following 4 h incubation of human leukaemic cells with the iron chelator 1-hydroxypyridine-2-thione (omadine). Its cytotoxic activity was comparable to that of the cytotoxic drug doxorubicin. At the same concentration two other effective iron chelators, desferrioxamine and 1,2-dimethyl-3-hydroxypyrid-4-one, were not cytotoxic. Addition of iron augmented the effect of omadine. It is suggested that the lipophilic properties of omadine and of its iron complex cause their intracellular accumulation and potent cytotoxic activity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kontoghiorghes GJ,Piga A,Hoffbrand AVdoi
10.1016/0014-5793(86)80813-4subject
Has Abstractpub_date
1986-08-18 00:00:00pages
208-12issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(86)80813-4journal_volume
204pub_type
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