Abstract:
:CCN2 plays a critical role in the development of mesenchymal tissues such as cartilage and bone, and the binding of CCN2 to various cytokines and receptors regulates their signaling.By screening a protein array, we found that CCN2 could bind to fibroblast growth factor receptors (FGFRs) 2 and 3, with a higher affinity toward FGFR2.We ascertained that FGFR2 bound to CCN2 and that the binding of FGFR2 to FGF2 and FGF4 was enhanced by CCN2.CCN2 and FGF2 had a collaborative effect on the phosphorylation of ERK and the differentiation of osteoblastic cells.The present results indicate the biological significance of the binding of CCN2 to FGFR2 in bone metabolism.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Aoyama E,Kubota S,Takigawa Mdoi
10.1016/j.febslet.2012.10.038subject
Has Abstractpub_date
2012-12-14 00:00:00pages
4270-5issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00830-7journal_volume
586pub_type
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