Abstract:
:The mechanism of stimulation of hepatic respiration by fatty acids was studied in isolated rat hepatocytes. Stimulation of respiration by fatty acids varied from about 35% to about 105% depending on chain length. The stimulatory effect of octanoate (1 mM) or oleate (0.5 mM) was prevented by oligomycin (2 micrograms/ml). With carboxyatractyloside (100 microM) and ouabain (2 mM) the stimulation of respiration was partially inhibited (by 50-70 and 50-60%, respectively). From these results it can be concluded that the increased rate of respiration after addition of fatty acids is coupled to ATP synthesis. A large part (50-60%) of this ATP is utilized by the (Na+ + K+)-ATPase.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Plomp PJ,van Roermund CW,Groen AK,Meijer AJ,Tager JMdoi
10.1016/0014-5793(85)80161-7subject
Has Abstractpub_date
1985-12-02 00:00:00pages
243-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(85)80161-7journal_volume
193pub_type
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