Elevated citrate levels in non-alcoholic fatty liver disease: the potential of citrate to promote radical production.

Abstract:

:Plasma citrate levels were found to be elevated in non-alcoholic fatty liver disease (NAFLD) patients. Cellular experiments indicated that increased citrate levels might originate from an excess of fatty acids. The impact of elevated citrate levels on oxidative stress was examined. It was found that citrate stimulated hydrogen peroxide induced intracellular oxidative stress in HepG2 cells. This was related to the promotion of iron mediated hydroxyl radical formation from hydrogen peroxide by citrate. The stimulating effect of citrate on the reactivity of iron promotes oxidative stress, a crucial process in the progression of NAFLD.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

van de Wier B,Balk JM,Haenen GR,Giamouridis D,Bakker JA,Bast BC,den Hartog GJ,Koek GH,Bast A

doi

10.1016/j.febslet.2013.06.019

subject

Has Abstract

pub_date

2013-08-02 00:00:00

pages

2461-6

issue

15

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(13)00466-3

journal_volume

587

pub_type

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