Abstract:
:Plasma citrate levels were found to be elevated in non-alcoholic fatty liver disease (NAFLD) patients. Cellular experiments indicated that increased citrate levels might originate from an excess of fatty acids. The impact of elevated citrate levels on oxidative stress was examined. It was found that citrate stimulated hydrogen peroxide induced intracellular oxidative stress in HepG2 cells. This was related to the promotion of iron mediated hydroxyl radical formation from hydrogen peroxide by citrate. The stimulating effect of citrate on the reactivity of iron promotes oxidative stress, a crucial process in the progression of NAFLD.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
van de Wier B,Balk JM,Haenen GR,Giamouridis D,Bakker JA,Bast BC,den Hartog GJ,Koek GH,Bast Adoi
10.1016/j.febslet.2013.06.019subject
Has Abstractpub_date
2013-08-02 00:00:00pages
2461-6issue
15eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00466-3journal_volume
587pub_type
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