DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans.


:Dicarbonyl/L-xylulose reductase (DCXR) converts l-xylulose into xylitol, and reduces various α-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification. In this study, we identified DHS-21 as the only DCXR ortholog in Caenorhabditis elegans. The dhs-21 gene is expressed in various tissues including the intestine, gonadal sheath cells, uterine seam (utse) cells, the spermathecal-uterus (sp-ut) valve and on the plasma membrane of spermatids. Recombinant DHS-21 was shown to convert L-xylulose to xylitol using NADPH as a cofactor. Dhs-21 null mutants of C. elegans show defects in longevity, reproduction and egg-laying. Knock-down of daf-16 and elt-2 transcription factors affected dhs-21 expression. These results suggest that DHS-21 is a bona fide DCXR of C. elegans, essential for normal life span and reproduction.




FEBS letters


Son le T,Ko KM,Cho JH,Singaravelu G,Chatterjee I,Choi TW,Song HO,Yu JR,Park BJ,Lee SK,Ahnn J




Has Abstract


2011-05-06 00:00:00














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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Cruz-Castañeda A,Olivares-Trejo JJ

    更新日期:2008-08-06 00:00:00

  • Rev-dependency of expression of human immunodeficiency virus type 1 gag and env genes.

    abstract::Structural gene expression of human immunodeficiency virus type 1 (HIV-1) requires a viral regulatory protein, Rev transactivator. We investigated Rev-dependency of HIV-1 gene expression by various reporter systems. Expression of unspliced and single-spliced viral mRNAs was demonstrated to be differentially dependent ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sakai H,Furuta RA,Tokunaga K,Kawamura M,Hatanaka M,Adachi A

    更新日期:1995-05-29 00:00:00

  • Cryogenic absorption spectra of hydroperoxo-ferric heme oxygenase, the active intermediate of enzymatic heme oxygenation.

    abstract::Using radiolysis with (32)P enriched phosphate as an internal source of ionizing radiation, the formation of hydroperoxo-ferric complex from oxy-ferrous precursor with a high yield was monitored at 77 K in heme oxygenase (HO) by means of optical absorption spectroscopy. Well-resolved absorption spectra (maxima at 421 ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Denisov IG,Ikeda-Saito M,Yoshida T,Sligar SG

    更新日期:2002-12-04 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Schwarz KR,Lanier SM,Carter EA,Graham RM,Homcy CJ

    更新日期:1985-08-05 00:00:00

  • Islet-activating protein prevents nicotinic acid-induced GTPase stimulation and GTP but not GTP gamma S-induced adenylate cyclase inhibition in rat adipocytes.

    abstract::The influence of islet-activating protein (IAP), a Bordetella pertussis toxin, was studied on adenylate cyclase and GTPase activities in rat adipocyte membranes. Pretreatment of rats or intact rat adipocytes with IAP did not affect adenylate cyclase inhibition by the stable GTP analog, GTP gamma S, whereas inhibition ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Aktories K,Schultz G,Jakobs KH

    更新日期:1983-05-30 00:00:00

  • Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme.

    abstract::A cDNA coding for a new subunit of soluble guanylyl cyclase with a calculated molecular mass of 81.7 kDa was cloned and sequenced. On the basis of sequence homology, the new subunit appears to be an isoform of the alpha 1-subunit and was designated alpha 2 as the new subunit is very similar to the alpha 1-subunit in t...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Harteneck C,Wedel B,Koesling D,Malkewitz J,Böhme E,Schultz G

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  • Apoptosis of mouse liver nuclei induced in the cytosol of carrot cells.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zhao Y,Jiang ZF,Sun YL,Zhai ZH

    更新日期:1999-04-01 00:00:00

  • N-terminal amino acid sequences of precursor and mature forms of alpha-1-antitrypsin.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Gross V,Kaiser C,Tran-Thi TA,Schmelzer E,Witt I,Plummer TH Jr,Heinrich PC

    更新日期:1983-01-24 00:00:00

  • The dual effects of the astrocyte-specific enhancer of the AQP4 M1 promoter.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Abe Y,Goda W,Ikeshima-Kataoka H,Yasui M

    更新日期:2017-12-01 00:00:00

  • The p18 component of the multisynthetase complex shares a protein motif with the beta and gamma subunits of eukaryotic elongation factor 1.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Quevillon S,Mirande M

    更新日期:1996-10-14 00:00:00

  • Mobilization of the hormone-sensitive calcium pool increases hepatocyte tight junctional permeability in the perfused rat liver.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Llopis J,Kass GE,Duddy SK,Farell GC,Gahm A,Orrenius S

    更新日期:1991-03-11 00:00:00

  • Biochemical characterization of the RNA-hydrolytic activity of a pumpkin 2S albumin.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Fang EF,Wong JH,Lin P,Ng TB

    更新日期:2010-09-24 00:00:00

  • Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle.

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Uversky VN,Fink AL

    更新日期:2002-07-03 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Biggar KK,Storey KB

    更新日期:2015-11-30 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sahin U,Blobel CP

    更新日期:2007-01-09 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nosaka K,Onozuka M,Konno H,Akaji K

    更新日期:2008-12-10 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Darrouzet E,Issartel JP,Lunardi J,Dupuis A

    更新日期:1998-07-10 00:00:00

  • Regulation of protein synthesis in lymphoblastoid cells during inhibition of cell proliferation by human interferons.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Clemens MJ,McNurlan MA,Moore G,Tilleray VJ

    更新日期:1984-06-04 00:00:00

  • The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt.

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    journal_title:FEBS letters

    pub_type: 信件


    authors: Zhang J,Yang Z,Ou J,Xia X,Zhi F,Cui J

    更新日期:2017-01-01 00:00:00

  • Synthesis of holo Paracoccus denitrificans cytochrome c550 requires targeting to the periplasm whereas that of holo Hydrogenobacter thermophilus cytochrome c552 does not. Implications for c-type cytochrome biogenesis.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sambongi Y,Ferguson SJ

    更新日期:1994-02-28 00:00:00

  • Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Park BH,Kim HG,Jin SW,Song SG,Jeong HG

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Maffucci T,Falasca M

    更新日期:2001-10-12 00:00:00

  • Primary structure of the alpha-subunit of vacuolar-type Na(+)-ATPase in Enterococcus hirae. Amplification of a 1000-bp fragment by polymerase chain reaction.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kakinuma Y,Igarashi K,Konishi K,Yamato I

    更新日期:1991-11-04 00:00:00

  • The first constant domain (C(H)1 and C(L)) of an antibody used as heterodimerization domain for bispecific miniantibodies.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Müller KM,Arndt KM,Strittmatter W,Plückthun A

    更新日期:1998-01-30 00:00:00

  • Diffusion of fluorescein-labelled molecules in suspensions of erythrocyte ghosts.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Järnefelt J,Laurent T,Rigler R

    更新日期:1988-12-19 00:00:00

  • The induction of adipose conversion in 3T3-L1 cells is associated with early phosphorylation of a 60-kDa nuclear protein.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Brandes R,Arad R,Bar-Tana J

    更新日期:1991-07-08 00:00:00

  • Glutathione and gamma-glutamyl transferases are involved in the formation of cadmium-glutathione complex.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Adamis PD,Mannarino SC,Eleutherio EC

    更新日期:2009-05-06 00:00:00

  • Increase in the molecular weight and radius of gyration of apocalmodulin induced by binding of target peptide: evidence for complex formation.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Izumi Y,Kuwamoto S,Jinbo Y,Yoshino H

    更新日期:2001-04-20 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Boerth NJ,Lincoln TM

    更新日期:1994-04-11 00:00:00

  • Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.

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    journal_title:FEBS letters

    pub_type: 信件


    authors: Sosnowski P,Turk D

    更新日期:2016-04-01 00:00:00