Abstract:
:The amino acid sequences of the polypeptide chains of the acetylcholine receptor have recently been published. From the hydrophilicity profiles, it has been proposed that residues 161-166 of the alpha-chain might be an important antigenic site. We have synthesised a peptide containing this sequence and raised antisera to it. Here we report that this peptide does not represent an important antigenic site on the molecule, and that this region is probably inaccessible to antibodies. Based on the known DNA sequences and hydrophilicity profiles of the receptor chains, we suggest that many regions of high hydrophilicity may represent inter-domain regions of proteins.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Juillerat MA,Barkas T,Tzartos SJdoi
10.1016/0014-5793(84)80224-0subject
Has Abstractpub_date
1984-03-12 00:00:00pages
143-8issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(84)80224-0journal_volume
168pub_type
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