Abstract:
:Peptides corresponding to the known sequence of turkey erythrocyte beta 1-adrenergic receptor were synthesized and the effects on receptor-mediated cyclase activation were measured. Peptides corresponding to the first and second intracellular loops (T61-71 and T138-159) inhibited at micromolar concentrations the hormone-dependent cyclase activation in turkey erythrocyte membranes. In contrast, the peptide corresponding to the C-terminal part of the third intracellular loop (T284-295) increased the cyclase activity in a hormone-independent manner. Peptides T338-353 and T2-10 and a number of synthetic peptides unrelated to the beta-adrenoceptor had no effect.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Palm D,Münch G,Dees C,Hekman Mdoi
10.1016/0014-5793(89)81015-4subject
Has Abstractpub_date
1989-08-28 00:00:00pages
89-93issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(89)81015-4journal_volume
254pub_type
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