CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis. Relationship to vasoactive intestinal polypeptide.


:The octapeptide Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr (peptide T) and two structural analogs are potent agonists of human monocyte chemotaxis, evincing identical rank potency orders as was previously shown for their inhibition of human immunodeficiency virus (HIV) envelope binding and T cell infectivity. Chemotactic activity could be inhibited by anti-CD4 monoclonal antibodies (Mabs), but not other mononuclear cell Mabs. The core peptide required for chemotactic activity is a pentapeptide related to the sequence Thr-Thr-Asn-Tyr-Thr. Homologous pentapeptides, identified by computer search, were detected in several other non-HIV-related viruses as well as the neuropeptide vasoactive intestinal polypeptide (VIP). The CD4 molecule, therefore, appears to be a recognition molecule for a small signal peptide ligand whose active sequence is a homolog of peptide T and which may be the neuropeptide VIP.




FEBS letters


Ruff MR,Martin BM,Ginns EI,Farrar WL,Pert CB




Has Abstract


1987-01-19 00:00:00














  • Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway.

    abstract::PPP2R2C encodes a gamma isoform of the subunit B55 subfamily, which is a regulatory subunit of Protein phosphatase type 2A (PP2A). Our study shows that PPP2R2C is downregulated in glioma cells and human brain cancer patient samples. Overexpression of PPP2R2C inhibited cancer cell proliferation both in vitro and in viv...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Fan YL,Chen L,Wang J,Yao Q,Wan JQ

    更新日期:2013-12-11 00:00:00

  • Live imaging of active fluorophore labelled Wnt proteins.

    abstract::For almost 30 years, Wnt proteins have been known as key regulators of many developmental decisions, including the formation of the embryonic axes, patterning of the CNS, limb bud outgrowth and segment polarity. However, live cell imaging of active Wnt proteins was rarely reported. Here, we have generated a Wnt2b-EGFP...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Holzer T,Liffers K,Rahm K,Trageser B,Ozbek S,Gradl D

    更新日期:2012-06-04 00:00:00

  • The dosage of chromatin proteins affects transcriptional silencing and DNA repair in Saccharomyces cerevisiae.

    abstract::Alterations in protein composition or dosage within chromatin may trigger changes in processes such as gene expression and DNA repair. Through transposon mutagenesis and targeted gene deletions in haploids and diploids of Saccharomyces cerevisiae, we identified mutations that affect telomeric silencing in genes encodi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Benbow SZ,DuBois ML

    更新日期:2008-02-20 00:00:00

  • A novel 45 kDa secretory protein from rat olfactory epithelium: primary structure and localisation.

    abstract::cDNA clones encoding the 45 kDa protein were isolated from a rat olfactory epithelium cDNA library and their inserts were sequenced. The reconstructed protein sequence comprises 400 amino acids with a calculated molecular mass of 46,026 Da. A homology was revealed between the amino acid sequence of the 45 kDa protein ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Merkulova MI,Andreeva SG,Shuvaeva TM,Novoselov SV,Peshenko IV,Bystrova MF,Novoselov VI,Fesenko EE,Lipkin VM

    更新日期:1999-04-30 00:00:00

  • Thermodynamic considerations on the formation of reactive species from hypochlorite, superoxide and nitrogen monoxide. Could nitrosyl chloride be produced by neutrophils and macrophages?

    abstract::Hypohalous acids are poor one-electron oxidizing agents, such that reactions with hydrogen peroxide to yield radical species are not feasible. However, the oxidation of superoxide by hypohalous acids can be a source of hydroxyl or haline radicals. The oxidation of nitrogen monoxide by hypochlorous acid is favourable, ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Koppenol WH

    更新日期:1994-06-20 00:00:00

  • A new mutation in the pufL gene responsible for the terbutryn resistance phenotype in Rubrivivax gelatinosus.

    abstract::Rubrivivax gelatinosus is a facultative phototrophic non-sulfur bacterium belonging to the beta subclass of the purple bacteria. A terbutryn-resistant mutant of R. gelatinosus has been isolated and characterized. Increased resistance levels to terbutryn (300-fold), atrazine (6-fold) and o-phenanthroline (3-fold) were ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ouchane S,Picaud M,Astier C

    更新日期:1995-10-23 00:00:00

  • Cbl-b-dependent degradation of FLIP(L) is involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells.

    abstract::Various molecular mechanisms are involved in the efficacy of arsenic trioxide (ATO) against malignant hematologic and some solid tumors. FLICE-like inhibitory protein (FLIP) is an inhibitor of apoptosis mediated by death receptors. In this study, we identified a new link between the down-regulation of cellular FLIP(L)...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zhang G,Liu J,Zhang Y,Qu J,Xu L,Zheng H,Liu Y,Qu X

    更新日期:2012-09-21 00:00:00

  • Mechanism and site of action of a ribosome-inactivating protein type 1 from Dianthus barbatus which inactivates Escherichia coli ribosomes.

    abstract::A single chain ribosome-inactivating protein with RNA N-glycosidase activity, here named Dianthin 29, was isolated from leaves of Dianthus barbatus L. Incubation of intact Escherichia coli ribosomes with Dianthin 29 and subsequent aniline treatment of the isolated rRNA releases a rRNA fragment of 243 nucleotides from ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Prestle J,Hornung E,Schönfelder M,Mundry KW

    更新日期:1992-02-10 00:00:00

  • Bradykinin-induced transient accumulation of inositol trisphosphate in neuron-like cell line NG108-15 cells.

    abstract::Studies were undertaken to further elucidate the mechanism(s) by which bradykinin-dependent phosphoinositide metabolism takes place in neuroblastoma X glioma hybrid NG108-15 cells [(1984) J. Biol. Chem. 259, 10201-10207] using [3H]inositol-labelled cells. Bradykinin produced net increases in the level of [3H]inositol ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yano K,Higashida H,Hattori H,Nozawa Y

    更新日期:1985-02-25 00:00:00

  • Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship.

    abstract::Frame shift mutations of the polyglutamine binding protein-1 (PQBP1) gene lead to total or partial truncation of the C-terminal domain (CTD) and cause mental retardation in human patients. Interestingly, normal Drosophila homologue of PQBP-1 lacks CTD. As a model to analyze the molecular network of PQBP-1 affecting in...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yoshimura N,Horiuchi D,Shibata M,Saitoe M,Qi ML,Okazawa H

    更新日期:2006-04-17 00:00:00

  • Association of high molecular weight DNA fragmentation with apoptotic or non-apoptotic cell death induced by calcium ionophore.

    abstract::Calcium ionophore (A23187)-induced high molecular weight (HMW) and internucleosomal DNA fragmentation were investigated in human leukemia cell lines. An apoptosis-sensitive cell line, HL-60, showed HMW, internucleosomal DNA fragmentation and morphological changes of apoptosis by A23187. MOLT-4, which is resistant to a...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kataoka A,Kubota M,Wakazono Y,Okuda A,Bessho R,Lin YW,Usami I,Akiyama Y,Furusho K

    更新日期:1995-05-15 00:00:00

  • Calcium-activated calcium permeability in parathyroid cells.

    abstract::The Ca2+ receptor mechanism of the parathyroid cell was studied using La3+ as a probe. La3+ was found to bind to the cell surface without further penetration. Measurements of 45Ca fluxes and the cytoplasmic Ca2+ concentration (Ca2+i) revealed a stimulatory component in the action of La3+ on Ca2+ permeability resulting...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Gylfe E,Larsson R,Johansson H,Nygren P,Rastad J,Wallfelt C,Akerström G

    更新日期:1986-09-01 00:00:00

  • Fibronectin is a hypoxia-independent target of the tumor suppressor VHL.

    abstract::The von Hippel-Lindau (VHL) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target genes, we subjected mRNA from VHL-deficient RCC cells (786-0-pRC) and a transfectant re-expressing wildtype VHL (786-0-VHL) to differential expression profiling. Amon...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bluyssen HA,Lolkema MP,van Beest M,Boone M,Snijckers CM,Los M,Gebbink MF,Braam B,Holstege FC,Giles RH,Voest EE

    更新日期:2004-01-02 00:00:00

  • Evolutionary specificity of hydrins, new hydroosmotic neuropeptides: occurrence of hydrin 2 (vasotocinyl-Gly) in the toad Bufo marinus but not in the viper Vipera aspis.

    abstract::Hydrin 2 (vasotocinyl-Gly), a hydroosmotic peptide resulting from differential processing of provasotocin and recently identified in frog neurohypophysis, has been looked for in the pituitary gland of an exotic toad (Bufo marinus) and of a reptile (Vipera aspis). Hydrin 2 has been found in the amphibian but not in the...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Michel G,Rouillé Y,Chauvet MT,Chauvet J,Acher R

    更新日期:1990-05-07 00:00:00

  • Modification of the GABA/benzodiazepine receptor with the arginine reagent, 2,3-butanedione.

    abstract::Treatment of either crude or purified preparations of the gamma-aminobutyrate (GABA)/benzodiazepine receptor complex with arginine-specific reagents resulted in a time- and concentration-dependent loss of [3H]muscimol binding activity. Following exposure to either 2,3-butanedione or phenylglyoxal (less than or equal t...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Widdows KB,Kirkness EF,Turner AJ

    更新日期:1987-09-28 00:00:00

  • Metabolic activation of 1,2-dibromoethane to a free radical intermediate by rat liver microsomes and isolated hepatocytes.

    abstract::A one-electron reductive metabolism of 1,2-dibromoethane (DBE) is described that gives rise to a free radical intermediate, which can be stabilized by a spin trapping agent and detected by electron spin resonance spectroscopy. Using rat liver microsomes or isolated hepatocytes from phenobarbitone pretreated animals, u...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Tomasi A,Albano E,Dianzani MU,Slater TF,Vannini V

    更新日期:1983-08-22 00:00:00

  • Suppression of HIV-1 transcription by beta-chemokines RANTES, MIP1-alpha, and MIP-1beta is not mediated by the NFAT-1 enhancer element.

    abstract::Soluble factors derived from human CD8+ T-lymphocytes inhibit HIV-1 replication by suppressing transcription from the viral long terminal repeat (LTR), an effect shown to be mediated in part by an NFAT-1 enhancer sequence. We show here that the CD8+ derived beta-chemokines, RANTES, MIP1-alpha, and MIP-1beta, known sup...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Handen JS,Rosenberg HF

    更新日期:1997-06-30 00:00:00

  • Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo: constitutive expression and enhancement in osteoarthritis and rheumatoid arthritis.

    abstract::Chemokines play a key role in modulating leukocyte functions at sites of inflammation. To assess chondrocyte contribution to the chemotactic environment of inflamed joints the intracellular content of CC and CXC chemokines was investigated. IL-8, GROalpha, MCP-1, RANTES, MIP-1alpha and MIP-1beta expression was evaluat...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Borzi RM,Mazzetti I,Macor S,Silvestri T,Bassi A,Cattini L,Facchini A

    更新日期:1999-07-23 00:00:00

  • How often does the myristoylated N-terminal latch of c-Abl come off?

    abstract::The myristoylated N-terminal latching to the C-terminal lobe of c-Abl was recently demonstrated to be an important regulatory element for the kinase, playing a role similar to that of the tyrosine-phosphorylated C-terminal tail of c-Src. A potential mechanism for activating c-Abl is the dissociation of the myristoylat...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zhou HX

    更新日期:2003-09-25 00:00:00

  • Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure.

    abstract::Uncoupling protein 3 (UCP3) may reduce mitochondrial ROS production, and thereby protect against mitochondrial dysfunction in skeletal muscle. UCP3 has been suggested to specifically fulfill this role under high-fat conditions. Here we show that UCP3 knockout mice indeed have elevated mitochondrial ROS production afte...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nabben M,Hoeks J,Moonen-Kornips E,van Beurden D,Briedé JJ,Hesselink MK,Glatz JF,Schrauwen P

    更新日期:2011-12-15 00:00:00

  • Concentration-dependent modulation of basic fibroblast growth factor action on multiplication and locomotion of human teratocarcinoma cells.

    abstract::A human teratoma cell line (Tera 2) was grown in serum-free medium, and the population multiplication was stimulated by the addition of 1-10 ng basic fibroblast growth factor (bFGF)/ml. The bFGF-effect was abrogated by the addition of protamine sulphate. When high concentrations of bFGF were added, a preferential effe...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Schofield PN,Granerus M,Lee A,Ektröm TJ,Engström W

    更新日期:1992-02-24 00:00:00

  • Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation.

    abstract::The enzyme telomerase is necessary for the synthesis and maintenance of telomere length. The catalytic subunit, telomerase reverse transcriptase (TERT), is regulated by interaction with the 90 kDa heat shock protein (HSP90) and by Akt-dependent phosphorylation. Here, we demonstrate that HSP90 and Akt physically intera...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Haendeler J,Hoffmann J,Rahman S,Zeiher AM,Dimmeler S

    更新日期:2003-02-11 00:00:00

  • Functional argument for the existence of an avian nitric oxide synthase in muscle mitochondria: effect of cold acclimation.

    abstract::We report the first evidence of a mitochondrial NO synthase (mtNOS) in bird skeletal muscle. In vitro, mtNOS activity stimulated by L-arginine reduced intermyofibrillar mitochondrial oxygen uptake and ATP synthesis rates, stimulated endogenous H(2)O(2) generation, but had no effect on oxidative phosphorylation efficie...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Rey B,Roussel D,Teulier L,Eyenga P,Degletagne C,Belouze M,Duchamp C

    更新日期:2011-01-03 00:00:00

  • Transforming growth factor-beta1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells.

    abstract::The transdifferentiation of hepatic stellate cells into myofibroblast-like cells and the proliferation of the transdifferentiated cells are controlled by TGF-beta1. Little is known about the intracellular signal transducers of TGF-beta1. In this paper we show that in cultured hepatic stellate cells TGF-beta1 induces a...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Reimann T,Hempel U,Krautwald S,Axmann A,Scheibe R,Seidel D,Wenzel KW

    更新日期:1997-02-10 00:00:00

  • Evidence for a novel phosphopantetheinyl transferase domain in the polyketide synthase for enediyne biosynthesis.

    abstract::The polyketide synthase associated with the biosynthesis of enediyne-containing calicheamicin contains a putative phosphopantetheinyl transferase (PPTase) domain. By cloning and expressing the C-terminal region of the polyketide synthase and in vitro phosphopantetheinylation assay, we found that the PPTase domain exhi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Murugan E,Liang ZX

    更新日期:2008-04-02 00:00:00

  • Requirement of pyk2 for the activation of the MAP kinase cascade induced by Ca(2+) (but not by PKC or G protein) in PC12 cells.

    abstract::The role of the Ca(2+)-activated tyrosine kinase, Pyk2, in the pleiotropic coupling of nerve cell stimulation to the MAP kinase cascade still remains undefined. Using a panel of PC12 clones, one of which was defective in Pyk2, we demonstrate (1) that the MAP kinase response induced by a [Ca(2+)](i) rise (following app...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Barsacchi R,Heider H,Girault J,Meldolesi J

    更新日期:1999-11-19 00:00:00

  • Cell type-specific processing of human Tau proteins in Drosophila.

    abstract::Accumulation of hyperphosphorylated Tau is associated with a number of neurodegenerative diseases collectively known as tauopathies. Differences in clinical and cognitive profiles among them suggest differential sensitivity of neuronal populations to Tau levels, phosphorylation and mutations. We used tissue specific e...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Grammenoudi S,Kosmidis S,Skoulakis EM

    更新日期:2006-08-21 00:00:00

  • Protein transport via the cpTat pathway displays cooperativity and is stimulated by transport-incompetent substrate.

    abstract::Kinetic analyses of cpTat-mediated protein transport across the thylakoid membrane were conducted, revealing three important characteristics of this translocation pathway. First, transport via the cpTAT system displays a non-Michaelis-Menten, sigmoidal rate-substrate relationship with an apparent Hill coefficient of 1...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Alder NN,Theg SM

    更新日期:2003-04-10 00:00:00

  • Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes.

    abstract::Incorporation of dioleoyl N-(monomethoxy polyethyleneglycol succinyl)phosphatidylethanolamine (PEG-PE) into large unilamellar liposomes composed of egg phosphatidylcholine:cholesterol (1:1) does not significantly increase the content leakage when the liposomes are exposed to 90% human serum at 37 degrees C, yet the li...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Klibanov AL,Maruyama K,Torchilin VP,Huang L

    更新日期:1990-07-30 00:00:00

  • The isolated proteolytic domain of Escherichia coli ATP-dependent protease Lon exhibits the peptidase activity.

    abstract::Selective protein degradation is an energy-dependent process performed by high-molecular-weight proteases. The activity of proteolytic components of these enzymes is coupled to the ATPase activity of their regulatory subunits or domains. Here, we obtained the proteolytic domain of Escherichia coli protease Lon by clon...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Rasulova FS,Dergousova NI,Starkova NN,Melnikov EE,Rumsh LD,Ginodman LM,Rotanova TV

    更新日期:1998-08-07 00:00:00