Abstract:
:The octapeptide Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr (peptide T) and two structural analogs are potent agonists of human monocyte chemotaxis, evincing identical rank potency orders as was previously shown for their inhibition of human immunodeficiency virus (HIV) envelope binding and T cell infectivity. Chemotactic activity could be inhibited by anti-CD4 monoclonal antibodies (Mabs), but not other mononuclear cell Mabs. The core peptide required for chemotactic activity is a pentapeptide related to the sequence Thr-Thr-Asn-Tyr-Thr. Homologous pentapeptides, identified by computer search, were detected in several other non-HIV-related viruses as well as the neuropeptide vasoactive intestinal polypeptide (VIP). The CD4 molecule, therefore, appears to be a recognition molecule for a small signal peptide ligand whose active sequence is a homolog of peptide T and which may be the neuropeptide VIP.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ruff MR,Martin BM,Ginns EI,Farrar WL,Pert CBdoi
10.1016/0014-5793(87)81265-6subject
Has Abstractpub_date
1987-01-19 00:00:00pages
17-22issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(87)81265-6journal_volume
211pub_type
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