Abstract:
:Ischemic preconditioning (IPrec) improves post-ischemic dysfunctions of the myocardium along with activation of protein kinase C isozymes including PKCdelta. Moreover, expression of cardio-protective determinants can reduce ischemic damages. Because IPrec is limited in aged hearts, we assessed in an experimental model the impact of aging on PKCdelta and selected protective proteins in the preconditioned myocardium from adult (< or =55) and older (> or =70 years) humans. Adult myocardium showed PKCdelta up-regulation after IPrec along with improved post-ischemic contractility. Although there was no functional benefit, PKCdelta increased in older myocardium as well. Subsequent mRNA analyses demonstrated that IPrec stabilizes the mRNA expression of protective proteins (Hsp70, Bcl-2/-xL, IAPs) in both aging groups. Moreover, older hearts revealed increase in post-ischemic Hsp90beta. Our study indicates, that IPrec conserves the expression of cardio-protective determinants in aged hearts despite limited functional recovery.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bartling B,Hilgefort C,Friedrich I,Silber RE,Simm Adoi
10.1016/s0014-5793(03)01342-5keywords:
subject
Has Abstractpub_date
2003-12-18 00:00:00pages
539-44issue
3eissn
0014-5793issn
1873-3468pii
S0014579303013425journal_volume
555pub_type
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