Abstract:
:Glucocorticoid hormones (GHs) regulate cell proliferation of neural progenitor cells (NPCs) contributing to reduction of neurogenesis after stress. We show here that dexamethasone (Dex) decreases BRUCE/Apollon (BRUCE) in cultured NPCs in a GH-receptor-dependent manner. Downregulation of BRUCE by Dex or using silencing RNA reduced the number of proliferating NPCs, whilst overexpression of BRUCE counteracted the effect of Dex. Dex also elevated the deubiquitinating enzyme, Usp8/Ubpy, which via Nrdp1 decreases BRUCE. The results show that BRUCE is a target for GHs in the NPCs, and that BRUCE controls cell division of NPCs and possibly of other stem cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sippel M,Rajala R,Korhonen L,Bornhauser B,Sokka AL,Naito M,Lindholm Ddoi
10.1016/j.febslet.2009.06.018subject
Has Abstractpub_date
2009-07-07 00:00:00pages
2213-7issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00465-7journal_volume
583pub_type
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