Abstract：
:To evaluate ozone damage to hairless mouse skin, two parameters of oxidative damage, vitamin E depletion and malondialdehyde (MDA) production, were measured in vitamin E-enriched and in control skin from mice exposed to ozone (10 ppm). A 5% vitamin E solution (tocotrienol-rich fraction, TRF) in polyethylene glycol (PEG) was applied to 2 sites on the back of hairless mice, PEG to 2 sites. After 2 h, the sites were washed, one of each pair of sites covered and the mice exposed ozone for 2 h. Ozone exposure (compared with covered sites) increased epidermal MDA in PEG-treated sites, while vitamin E was unchanged. In contrast, ozone exposure significantly depleted vitamin E in TRF-treated sites, while significant MDA accumulation was prevented. This is the first demonstration that ozone exposure causes damage to cutaneous lipids, an effect which can be attenuated by vitamin E application.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Thiele JJ,Traber MG,Podda M,Tsang K,Cross CE,Packer Ldoi
10.1016/s0014-5793(96)01463-9subject
Has Abstractpub_date
1997-01-20 00:00:00pages
167-70issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(96)01463-9journal_volume
401pub_type
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