Generation of VV-hemorphin-7 from globin by peritoneal macrophages.

Abstract:

:Bovine globin has been incubated with mice peritoneal macrophages in order to study its hydrolysis by lysosomal enzymes, among which chiefly cathepsin D. Analysis of resulting peptides, by reversed-phase high-performance liquid chromatography (RP-HPLC), showed the release of a bioactive peptide, VV-hemorphin-7. When a carboxyl proteinase inhibitor such as pepstatin A was added, no hemorphin was generated. Our results clearly demonstrated that VV-hemorphin-7 generation was principally due to cathepsin D. This study allowed us to hypothesize a possible pathway for in vivo hemorphins appearance from globin catabolism by macrophages.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Dagouassat N,Garreau I,Sannier F,Zhao Q,Piot JM

doi

10.1016/0014-5793(96)00144-5

subject

Has Abstract

pub_date

1996-03-11 00:00:00

pages

37-42

issue

1-2

eissn

0014-5793

issn

1873-3468

journal_volume

382

pub_type

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