Abstract:
:Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only partially effective so far, ion channel modulation as a future strategy was brought into focus. Here, we review the status quo concerning recent findings from ion channel research in MS and its animal model, experimental autoimmune encephalomyelitis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ehling P,Bittner S,Budde T,Wiendl H,Meuth SGdoi
10.1016/j.febslet.2011.03.065subject
Has Abstractpub_date
2011-12-01 00:00:00pages
3836-42issue
23eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00231-6journal_volume
585pub_type
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