Abstract:
:The colony-forming ability of catalase-deficient Escherichia coli mutant genetically modified to produce eicosapentaenoic acid (EPA) showed less decrease than in a control strain producing no EPA, when treated with 0.3mM hydrogen peroxide (H(2)O(2)) under non-growth conditions. H(2)O(2)-induced protein carbonylation was enhanced in cells lacking EPA. The amount of fatty acids was decreased more significantly for cells lacking EPA than for those producing EPA. Much lower intracellular concentrations of H(2)O(2) were detected for cells with EPA than those lacking EPA. These results suggest that cellular EPA can directly protect cells against oxidative damage by shielding the entry of exogenously added H(2)O(2).
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nishida T,Orikasa Y,Watanabe K,Okuyama Hdoi
10.1016/j.febslet.2006.11.030subject
Has Abstractpub_date
2006-12-11 00:00:00pages
6690-4issue
28-29eissn
0014-5793issn
1873-3468pii
S0014-5793(06)01349-4journal_volume
580pub_type
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